| 张先娇,苗 毅,曲书毅,杨 城,谢祥军,刘寒强,王水利.TLR4基因rs10983755位点单核苷酸多态性与非小细胞肺癌易感性的相关性研究[J].现代生物医学进展英文版,2018,(4):701-704. |
| TLR4基因rs10983755位点单核苷酸多态性与非小细胞肺癌易感性的相关性研究 |
| Correlative Analysis between SNP rs10983755 in TLR4 Gene and NSCLC Susceptibility |
| Received:October 12, 2017 Revised:October 30, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.04.021 |
| 中文关键词: Toll样受体4 单核苷酸多态性 非小细胞肺癌 |
| 英文关键词: Toll-like receptors 4 Single nucleotide polymorphism Non-small cell lung cancer |
| 基金项目:陕西省自然科学基金项目（2014JQ4130） |
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| 中文摘要: |
| 摘要 目的：探讨TLR4基因rs10983755 A/G单核苷酸多态性(SNP)与非小细胞肺癌(NSCLC)易感性的相关性。方法：采用病例-对照研究方法纳入160例非小细胞肺癌患者(NSCLC组)和160例健康对照(NC组)，利用MassARRAY飞行时间质谱生物芯片系统对TLR4 基因rs10983755位点的单核苷酸多态性进行分型检测，并进行统计学分析。结果：rs10983755等位基因频率在中国汉族NSCLC患者和健康人群中的分布差异具有统计学意义(P<0.05)，A等位基因携带者NSCLC发生风险是G等位基因携带者的1.821倍(95% CI=1.124～2.906)；rs10983755基因型频率在NSCLC患者和健康人群中分布差异具有统计学意义(P<0.05)，AA+AG基因型NSCLC发生风险是GG基因型的2.103倍(95% CI=1.118～3.898)。结论：TLR4基因rs10983755 A/G单核苷酸多态性与NSCLC的易感性显著相关，A是风险等位基因。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation of rs10983755 A/G SNP of TLR4 with non-small cell lung cancer (NSCLC) susceptibility in a population in Shaanxi province. Methods: Based on case-control study, MassARRAY platform which based on MALDI-TOF mass spectrometry technology was used to identify the genotypes of rs10983755 of TLR4 gene in 160 cases of NSCLC patients and 160 cases of healthy control in a population in Shaanxi province. Then, we did statistics analysis with epidemiological data and clinical data to find the association of SNP with NSCLC susceptibility. Results: There was a significant difference in the genotypes of the TLR4 SNP rs10983755 between the NSCLC patients and controls (P<0.05). NSCLC patients with the A allele showed a significantly higher risk of NSCLC (P<0.05) compared with the G allele, indicating that the A allele SNP rs10983755 was associated with NSCLC risk (OR=1.821, 95% CI=1.124～2.906). Compared with GG genotype, AA+AG genotype was significantly associated with increased risk of NSCLC (OR=2.103, 95% CI=1.118～3.898). Conclusion: The single nucleotide polymorphism of the rs10983755 of TLR4 gene was correlated with NSCLC susceptibility in a population in Shaanxi province，and the allele A was a risk allele. |
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