| 林炳岐,李 峰,马 捷,刘 燕,戴 宁,张炜悦,韩晨霞,陈旻丹,于姣姣,张 蔚,吴凤芝.基于GABA能系统通路探讨失眠的机制[J].现代生物医学进展英文版,2018,(3):565-568. |
| 基于GABA能系统通路探讨失眠的机制 |
| Based on GABA Acid System Access to Explore the Mechanism of Insomnia |
| Received:April 15, 2017 Revised:May 11, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.03.037 |
| 中文关键词: 失眠 γ-氨基丁酸（GABA） GABA能系统通路 |
| 英文关键词: Insomnia Gamma-aminobutyric Acid（GABA） GABA acid system access |
| 基金项目:北京市自然科学基金项目（7162124）；北京市中医药科技项目（JJ2014-64） |
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| 中文摘要: |
| 摘要：γ-氨基丁酸（GABA）是中枢神经系统中一种重要的抑制性神经递质，能够抑制兴奋的神经元，对神经元有保护性作用。许多研究表明，GABA 能系统的异常和失眠有着密切的关系。但是，大部分的有关失眠的实验研究主要以GABA含量及其受体的变化为重点，对于GABA能系统通路上其他环节和失眠关系的研究比较少。而GABA能系统通路中GABA的合成、转运和代谢环节发生变化，都会间接地影响GABA的含量以及生物功能，进而影响睡眠。因此，本文经过对有关失眠的实验和理论研究的相关文献进行分析和总结，并以GABA能系统通路为基础，探讨该通路上的合成、转运和代谢三个环节和失眠发生的关系，希望有助于同道们全方位地把握失眠的动态机制，了解通路中不同环节之间相互变化的关系，为失眠的研究提供思路和方法。 |
| 英文摘要: |
| ABSTRACT: Gamma-aminobutyric Acid（GABA）is an important inhibitory neurotransmitter in the central nervous system. It can protect the neurons by restraining excited neurons. Many studies have shown that the abnormity of GABA acid system access is closely related with insomnia. However the most of studies are mainly focused on the changes of GABA and its receptors, and there is less re- search about the relation between insomnia and other links of GABA acid system access. The GABA acid system access, including the GABA synthesis, transport and metabolism, will affect sleep by influencing the content of GABA and its biological function. Thus, this paper analyzed and summarized many experimental and theoretical studies about insomnia, then on the basis of GABA can system ac- cess, to explore the relation between access of synthesis, transport and metabolism and insomnia. In this way, we can comprehensively grasp the dynamic mechanism of insomnia, understand the relations of access among different links, and provide ideas and methods for the research on insomnia. |
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