| 黄 梅,谭玲玲,杨 霜,王 露,朱梦莲,王 丽,樊均明.慢性肾脏病患者血清GDF-15的水平及临床意义[J].现代生物医学进展英文版,2018,(3):489-492. |
| 慢性肾脏病患者血清GDF-15的水平及临床意义 |
| Clinical Significance of Growth Differentiation Factor-15 in Chronic Kidney Disease |
| Received:September 23, 2017 Revised:October 17, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.03.019 |
| 中文关键词: 慢性肾脏病 生长分化因子-15 相关性分析 |
| 英文关键词: Chronic kidney disease Growth differentiation factor -15 Correlative analysis |
| 基金项目:四川省科技厅支撑计划项目（14ZC0027）；四川省卫计委重点项目（16ZD034）；四川省教育厅科研创新团队(自然科学)项目（17TD0046）；国家大学生创新创业项目（201610632024） |
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| 中文摘要: |
| 摘要 目的：探讨慢性肾脏病(Chronic Kidney Disease，CKD)患者血清生长分化因子-15(Growth Differentiation Factor -15，GDF-15)的表达及与其他肾功能相关临床指标的相关性。方法：选取西南医科大学附属医院2017年3月至2017年7月健康体检中心30例健康体检者对照组及肾病内科、内分泌科、心内科住院病房各期CKD患者150例，采用ELISA法测试验检其血清GDF-15水平。结果：除去CKD1期外，各期CKD患者eGFR及血清SCr、BUN、GDF-15水平均明显高于健康对照组，差异具有统计学意义(P<0.05)；随着CKD分期的增加，患者血清SCr、BUN、GDF-15浓度逐渐增加，且各组之间差异具有统计学意义(P<0.05)。CKD3组患者血清UA浓度明显高于健康对照组、CKD1组(P<0.05)，CKD4组、CKD5组血清UA浓度明显高于健康对照组、CKD1组及CKD2组(P<0.05)。GDF-15水平与eGFR水平呈负相关(r=-0.768，P<0.01)，与SCr水平呈正相关(r=0.751，P<0.01)，与BUN水平呈正相关(r=0.764，P<0.01)，与UA水平呈正相关(r=0.470，P<0.01)。结论：GDF-15与慢性肾脏病的发生与发展密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the serum levels of growth differentiation factor-15(GDF-15) at different stages of patients with chronic kidney disease(CKD) and analyze its correlation with other clinical indicators related to renal function. Methods: One hun- dred and fifty patients with CKD and 30 healthy cases treated in the Affiliated hospital of Southwest Medical University from March 2017 to July 2017 were selected as disease group and control group respectively. Enzyme linked immunosorbent assay was used to detect the serum GDF-15 level of participants. Results: The eGFR and serum levels of GDF-15, SCr, BUN in patients with CKD2-5 were higher than that in the control group(P<0.05). With the increase of CKD stage, the levels of SCr, BUN, GDF-15 of patients increased gradually(P<0.05). The concentration of UA in patients with CKD3 was significantly higher than that of the control group and patients with CKD1(P<0.05). The concentration of UA in the patients with CKD4, CKD5 were significantly higher than those of control group, patients with CKD1and CKD2(P<0.05). Correlation analysis showed that serum GDF-15 level was positively correlated with the levels of SCr, BUN, UA (r=0.751, 0.764, 0.470, P<0.01), and negatively correlated with eGFR (r=-0.768, P<0.01). Conclusion: Serum GDF-15 level is closely related to the occurrence and development of chronic kidney disease. |
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