| 凌 华,刘 斌,梁 霄,谢先丰,谢科宇,孙 燕.0.5 μg(kg·h)维持剂量右美托咪定麻醉对肺癌根治术患者血清IL-6、NSE、S100β蛋白水平的影响[J].现代生物医学进展英文版,2018,(3):477-480. |
| 0.5 μg(kg·h)维持剂量右美托咪定麻醉对肺癌根治术患者血清IL-6、NSE、S100β蛋白水平的影响 |
| Effects of 0.5 μg (kg·h) Dose of Dexmedetomidine on the serum IL-6, NSE and S100β Protein Levels of Patients with Lung Cancer Radical Surgery |
| Received:June 29, 2017 Revised:July 25, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.03.016 |
| 中文关键词: 肺癌根治术 右美托咪定 白细胞介素 神经元特异性烯醇化酶 S100β蛋白 |
| 英文关键词: Lung cancer radical surgery Dexmedetomidine Interleukin-6 Neuron-specific enolase S100β protein |
| 基金项目:四川省卫生厅基金项目(080218) |
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| 中文摘要: |
| 摘要 目的：探讨肺癌根治术应用0.5 μg(kg?h)维持剂量右美托咪定(Dex)辅助麻醉对患者血清白细胞介素-6(IL-6)、神经元特异性烯醇化酶(NES)及S100β蛋白水平的影响。方法：选取我院2016年3月~2017年3月收治并择期行肺癌根治术治疗的92例患者，采取随机数字表法均分为两组。所有患者均采取相同的常规静吸复合麻醉，于麻醉诱导前15 min(T1)静脉滴注负荷剂量为1 μg/kg的Dex。观察组在此基础上以0.5 μg/(kg?h)速度持续静脉泵注Dex至术毕前10 min，对照组以等剂量生理盐水重复以上操作。记录比较两组T1、单肺通气前(T2)、单肺通气60 min(T3)、术毕时刻(T4)、术后24 h(T5)血清IL-6、NSE、S100β蛋白水平及术后不良反应的发生情况。结果：与T1时间点对比，两组T2、T3、T4、T5时血清IL-6、NSE、S100β水平均显著升高(P<0.01)，且观察组在T2、T3、T4、T5时血清IL-6、S100β水平显著低于对照组同时(P<0.01)。观察组术后不良反应率较对照组低(P<0.05)。结论：肺癌根治术应用0.5 μg(kg?h)维持剂量右美托咪定(Dex)辅助麻醉更能有效降低术患者IL-6、NSE、S100β蛋白水平，抑制机体炎症反应，减轻脑损伤，且安全性高。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effect of 0.5 μg(kg?h) maintenance dose of dexmedetomidine (Dex) on the serum inter- leukinIL-6 (IL-6), neuron-specific enolase (NSE) and S100β protein levels of patients with lung cancer radical surgery. Methods: 92 cases of patients undergoing elective resection of lung cancer treatment in our hospital from March 2016 to March 2017 were selected as re- search objectives and randomly divided into two groups. All cases were provided with the same conventional intravenous combined anes- thesia, Dex was administered at a dose of 1 μg/kg intravenously at 15 min before induction of anesthesia (T1). The observation group was given continuous intravenous injection of Dex at a rate of 0.5 μg(kg?h) till 10 mins before operation, the above procedure was re- peated with equal dose of saline to the control group. The serum IL-6, NSE, S100β levels at T1 , before single lung ventilation (T2), sin- gle lung ventilation (T3), operation finished time (T4), postoperative 24 h (T5) as well as the incidence of postoperative adverse reaction were com- pared between two groups. Results: The serum IL-6, NSE and S100β protein levels at T2, T3, T4, T5 were significant higher than those at T1(P<0.01), which were significantly lower in the observation group than those of the control group at same time points (P<0.01). The in- cidence of postoperative adverse reactions in observation group was significantly lower than that of the control group (P<0.05). Conclusion: 0.5 μg(kg?h) maintenance dose of Dex assisted anesthesia helps patient to reduce the serum IL-6, NSE, S100β protein levelS inhib- it the inflammatory response and reduce brain damage WITH high safely. |
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