| 杨林林,柏明珠,吴 煜,丰有吉,张箴波.促排卵药物与卵巢癌关系的研究进展[J].现代生物医学进展英文版,2018,(2):377-380. |
| 促排卵药物与卵巢癌关系的研究进展 |
| Research Progress of the Relationship between Ovulation Induction and Ovarian Carcinomas |
| Received:February 27, 2017 Revised:March 23, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.02.041 |
| 中文关键词: 不孕 促排卵治疗 卵巢癌 |
| 英文关键词: Infertility Ovulation treatment Ovarian carcinomas |
| 基金项目:国家自然科学基金项目（81272883，81370074）；上海市卫生局科研项目（XYQ2013119） |
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| 中文摘要: |
| 摘要：随着人们生活环境和生活方式的改变，目前不孕症的发病率逐年增高，体外受精-胚胎移植技术IVF的发展有效解决了女性不孕问题，然而这一技术所采用的高剂量促排卵药物所引起的体内激素水平的改变以及短时间内大量排卵导致卵巢表面上皮的反复损伤与修复是否与后期卵巢癌的发生有关联？针对这一问题，国内外学者曾对此进行了一系列机制研究及大量的流行病学调查，但是已完成的研究中仍存在随访时间较短、采用IVF治疗的女性平均年龄较低等问题，使得促排卵药物使用与卵巢癌的关系仍没有确切定论。本文对国内外促排卵药物与卵巢癌关系的研究进展进行了综述。 |
| 英文摘要: |
| ABSTRACT: The increasing infertility in recent decades attributes to the side effects of multiple factors, including pollution, aberrant hormones. Fortunately, the vitro fertilization-embryo transfer technology is available to overcome this issue. However, it is not clear whether the high dose of follicle stimulating hormone used to ovulation, alteration of hormonal level, even the repeated damage and subsequent repair cycles, could increase the risk of ovarian tumor development. Upon this, increasing evidence has gone on some relevant epidemiologic studies, we also have carried out some mechanical researches regarding how follicle stimulating hormone affects ovarian cancers. But, the designs of the established studies, to some degree, have limitations on the short-term follow-up and the lower mean age of the treated women and so on. In summary, there is still no significant evidence about the association between fertility drug use and ovarian tumor risk. Now, we summarize their contributions as follows. |
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