| 罗劼妍,黄 浩,黄胜兰,陈 炎,陈 洁.肺癌患者外周血淋巴细胞亚群水平的表达及临床意义[J].现代生物医学进展英文版,2018,(2):326-329. |
| 肺癌患者外周血淋巴细胞亚群水平的表达及临床意义 |
| Expression and Clinical Significance of Peripheral Blood Lymphocyte Subsets in Patients with Lung Cancer |
| Received:May 12, 2017 Revised:June 07, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.02.029 |
| 中文关键词: 肺癌 外周血淋巴细胞亚群 表达 临床意义 |
| 英文关键词: Lung cancer Peripheral blood lymphocyte subsets Expression Clinical significance |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨肺癌患者外周血淋巴细胞亚群水平的表达及临床意义。方法：选择2016年3月~2017年3月期间我院收治的88例肺癌患者作为研究组，选择同期于我院进行健康体检的88例受检者作为对照组。两组研究对象均通过流式细胞仪检测外周血T淋巴细胞亚群水平。观察对比两组研究对象外周血T淋巴细胞亚群的表达水平，以及研究组不同临床病理特征患者外周血T淋巴细胞亚群的表达水平。结果：研究组CD4+/CD8+、CD4+、CD3+表达水平均低于对照组，CD8+表达水平高于对照组，差异具有统计学意义（P<0.05）。研究组Ⅲ期与Ⅳ期患者CD4+/CD8+、CD4+、CD3+表达水平均低于Ⅰ期与Ⅱ期，Ⅲ期与Ⅳ期患者CD8+表达水平高于Ⅰ期与Ⅱ期（P<0.05）；小细胞肺癌患者CD4+/CD8+、CD4+、CD3+表达水平均低于非小细胞肺癌患者，CD8+表达水平高于非小细胞肺癌患者，差异具有统计学意义（P<0.05）。不同性别、年龄、肿瘤分化程度肺癌患者CD4+/CD8+、CD8+、CD4+、CD3+水平无统计学差异（P>0.05）。结论：肺癌患者外周血淋巴细胞亚群水平的表达呈现异常状态，且表达水平与疾病的分期和病理分型有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression and clinical significance of peripheral blood lymphocyte subsets in patients with lung cancer. Methods: A total of 88 patients with lung cancer,who were admitted to Second People's Hospital of Yibin from March 2016 to March 2017, were chosen as study group; 88 subjects, who underwent physical examination in the hospital during the same period, were chosen as control group.The peripheral blood T lymphocyte subsets of the patients of the two groups were detected by flow cytometry. The expression levels of peripheral blood T lymphocyte subsets of the patients in the two groups were observed and compared, and the expression levels of peripheral blood T lymphocyte subsets of the patients with different clinicopathological characteristics in the study group were analyzed. Results: The expression levels of CD4+/CD8+, CD4+ and CD3+ in the study group were lower than those in the control group, the expression level of CD8+ was higher than that in the control group, the difference was statistically significant (P<0.05). The expression levels of CD4+/CD8+, CD4+ and CD3+ of the patients of the study group in stage III and IV were lower than those in stage I and II, and the expression level of CD8+ in stage III and IV was higher than that in stage I and II (P<0.05). The expression levels of CD4+/CD8+, CD4+ and CD3+ in the patients with small cell lung cancer were lower than those in the patients with non-small cell lung cancer, the expression level of CD8+ was higher than that in the patients with non-small cell lung cancer,the difference was statistically significant (P<0.05). There were no significant differences in the levels of CD4+/CD8+, CD4+ and CD3+ among the patients with different gender, age and tumor differentiation (P>0.05). Conclusion: The expression of peripheral blood lymphocyte subsets in the patients with lung cancer is abnormal,and the expression level is related to the stage and pathological type of lung cancer. |
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