| 朱云海,许云飞,陈耀武,孟 军,舒 畅.高龄Ⅲ型前列腺炎患者血清和前列腺液中神经生长因子、炎性因子的表达水平及临床意义[J].现代生物医学进展英文版,2018,(2):272-275. |
| 高龄Ⅲ型前列腺炎患者血清和前列腺液中神经生长因子、炎性因子的表达水平及临床意义 |
| Expressions and Clinical Significances of Nerve Growth Factor and Inflammatory Factors in Serum and Expressed Prostatic Secretions in the Elderly Patients with Prostatitis |
| Received:May 06, 2017 Revised:May 30, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.02.017 |
| 中文关键词: 慢性前列腺炎 高龄 神经生长因子 炎性因子 慢性前列腺症状指数 |
| 英文关键词: Chronic prostatitis Elderly Nerve growth factor Inflammatory factor Chronic prostatitis symptom index |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨高龄Ⅲ型慢性前列腺炎(CP)患者血清和前列腺液(EPS)中神经生长因子(NGF)、炎性因子的表达水平及其临床意义。方法：收集2015年5月~2016年12月我院收治的150例高龄Ⅲ型CP患者(CP组)，其中ⅢA型81例，ⅢB型69例，另选择150例健康体检者作为对照(对照组)。采用双抗体夹心酶联免疫吸附法(ABC-ELISA)检测其血清、EPS中NGF、IL-8和TNF-α的表达水平，分析NIH-CPSI、NGF、IL-8和TNF-α之间的相关性。结果：CP组血清、EPS中TNF-α、IL-8、NGF水平均明显高于对照组(P<0.05)；与IIIB型患者比较，IIIA型患者TNF-α、IL-8水平明显升高(P<0.05)；EPS中TNF-α、IL-8、NGF水平均明显高于血清(P<0.05)。IIIB型患者的NIH-CPSI症状评分明显低于IIIA型(P<0.05)。CP患者EPS中NGF和TNF-α、IL-8均呈显著正相关(P<0.05)；血清中NGF和TNF-α、IL-8亦呈显著正相关(P<0.05)。III型CP患者血清、EPS中，TNF-α、IL-8、NGF与NIH-CPSI呈显著正相关(P<0.05)。结论：高龄III型CP患者血清、EPS中TNF-α、IL-8、NGF表达水平明显升高，且与NIH-CPSI明显相关，联合检测有助于评估III型CP患者的病情严重程度。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the expressions and clinical significances of nerve growth factor(NGF) and inflammatory factors in serum and expressed prostatic secretions(EPS) in the elderly patients with chronic prostatitis(CP). Methods: Patients with Type Ⅲ CP (CP group) who were admitted from December 2013 to December 2016 and 150 cases of healthy controls were selected. CP group included 81 cases of Type ⅢA CP, 69 cases of Type ⅢB CP. The NGF, IL-8 and TNF-α levels in serum and EPS were detected by ABC-ELISA, and the correlation of NIH-CPSI, NGF, IL-8 with TNF-α were analyzed. Results: The levels of TNF-α, IL-8 and NGF in serum, EPS in CP group were significantly higher than those of the control group(P<0.05). Compared with the type IIIB CP, the levels of TNF-α, IL-8 in type IIIA CP were significantly increased(P<0.05). The levels of TNF-α, IL-8 and NGF in EPS were significantly higher than those in the serum(P<0.05). The NIH-CPSI symptom scores of patients with type IIIB CP was significantly lower than that of patients with type IIIA CP (P<0.05). The levels of TNF-α, IL-8 in serum and EPS of CP patients had significantly positive correlation with NGF(P<0.05). There was positive correlation of TNF-α, IL-8, NGF with NIH-CPSI in serum and EPS of CP patients(P<0.05). Conclusion: The levels of TNF-α, IL-8, NGF in serum and EPS of elderly patients with type III CP were highly expressed and closely correlated with the NIH-CPSI. Combination detection of TNF-α, IL-8, NGF could contribute to evaluate the severity of CP. |
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