| 李 敏,李 虎,陈海为,朱玉峰,黄金燕,薛 旺,欧东波,林尧明,王 逵.胺碘酮治疗冠心病心律失常及其对血流动力学的影响研究[J].现代生物医学进展英文版,2018,(1):130-134. |
| 胺碘酮治疗冠心病心律失常及其对血流动力学的影响研究 |
| Effect of Amiodarone on Coronary Heart Disease Arrhythmia and Hemodynamics |
| Received:May 01, 2017 Revised:May 24, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.01.029 |
| 中文关键词: 胺碘酮 冠心病心律失常 临床疗效 血流动力学 不良反应 |
| 英文关键词: Amiodarone Arrhythmia of coronary heart disease Clinical efficacy Hemodynamics Adverse reactions |
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| 中文摘要: |
| 摘要 目的：研究胺碘酮治疗冠心病心律失常（CHDA）的临床疗效及其对血流动力学的影响。方法：选择2015年1月～2016年12月于我院心血管内科治疗的CHDA患者156例，依据随机数字表法将所有CHDA患者分为观察组（n=78）与对照组（n=78）。对照组给予常规治疗，观察组在对照组基础上给予胺碘酮治疗。观察两组治疗后血压、平均动脉压及心率情况，治疗前后两组纤维蛋白原（Fb）、血细胞比容（HCT）、细胞沉降率（ESR）、血浆比黏度（np）、高切变率下全血黏度（nbh）及低切变率下全血黏度（nbl）等血流动力学指标，治疗前后两组QTc间期、PR间期及QRs波时限等心电图指标，临床疗效及不良反应。结果：治疗后，观察组血压、平均动脉压、心率及Fb、HCT、ESR、np、nbh、nbl等血流动力学指标均低于对照组，QTc间期高于对照组，差异有统计学意义（P＜0.05）。观察组总有效率（93.59%）高于对照组（78.21%），差异有统计学意义（P＜0.05）。观察组不良发应发生率（2.56%）与对照组（0.00%）差异无统计学意义（P＞0.05） 。结论：胺碘酮治疗CHDA可有效改善患者血流动力学，临床疗效显著，不良反应少，值得临床应用。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical efficacy of amiodarone in the treatment of coronary heart disease arrhythmia (CHDA) and its effect on haemodynamics. Methods: A total of 156 patients with CHDA, who were treated in Department of Cardiovasology of No. 422 Hospital of PLA from January 2015 to December 2016, were selected and randomly divided into observation group (n=78) and control Group (n=78). The control group was performed conventional therapy, on the basis of which, the observation group was treated with amiodarone. The blood pressure, mean arterial pressure and heart rate of the patients in the two groups were observed after treat- ment. The hemodynamic indexes, including fibrinogen(Fb), hematocrit(HCT), erythrocyte sedimentation rate (ESR), plasma viscosity (np) and whole blood viscosity at high shear rate(nbh) and that at low shear rate(nbl), the cardiograph parameters including Q-Tc interval, PR interval and QRS duration, the clinical efficacy and adverse reactions of the two groups were observed. Before and after treatment. Results: After treatment, the levels of blood pressure, mean arterial pressure, heart rate, Fb, HCT, ESR, np, nbh, nbl and other hemody- namic indexes in the observation group were lower than those in the control group, the Q-Tc interval was higher than that in the control group, the difference was statistically significant (P<0.05). The total effective rate(93.59%) of Observation group was higher than that(78.21%) of control group, the difference was statistically significant (P<0.05). The incidence (2.56%) of adverse reactions in the obser- vation group was not significantly different from that（0.00%） in the control group (P>0.05). Conclusion: In the treatment of CHDA, amiodarone can effectively improve the hemodynamics of patients, with significant clinical efficacy and less adverse reactions, which is worthy of clinical application. |
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