| 杨胜兰,向正国,陈旭峰,郑 扬,李科军.奥曲肽辅助十二指肠镜治疗急性水肿型胆源性胰腺炎疗效及对炎症反应的影响[J].现代生物医学进展英文版,2018,(1):117-121. |
| 奥曲肽辅助十二指肠镜治疗急性水肿型胆源性胰腺炎疗效及对炎症反应的影响 |
| Clinical Effect of Octreotide-assisted Duodenoscopy on the Acute Edematous Biliary Pancreatitis and Its Effect on the Inflammatory Response |
| Received:May 08, 2017 Revised:May 31, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.01.026 |
| 中文关键词: 奥曲肽 十二指肠镜 急性水肿型胆源性胰腺炎 炎症反应 |
| 英文关键词: Octreotide Duodenoscopy Acute edematous biliary pancreatitis Inflammatory reaction |
| 基金项目:江苏省卫生厅科技项目(Y201522) |
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| 中文摘要: |
| 摘要 目的：探讨奥曲肽辅助十二指肠镜治疗急性水肿型胆源性胰腺炎疗效及对炎症反应的影响。方法：选择急性水肿型胆源性胰腺炎患者100例，随机分为研究组与对照组各50例，两组患者均给予禁食、抗感染、营养支持、酶抑制剂治疗，对照组同期给予十二指肠镜治疗，研究组同期给予奥曲肽辅助十二指肠镜治疗，比较两组腹痛缓解时间，白细胞(WBC)、体温恢复正常时间，治疗前(T0)、治疗3d(T1)、治疗7d(T2)血、尿淀粉酶水平与炎症因子CRP、IL-6、TNF-α水平的变化。结果：①研究组腹痛缓解时间、WBC、体温恢复正常时间均较对照组明显缩短(P＜0.05)；②两组患者T1、T2血、尿淀粉酶水平均较T0明显降低，且T2血、尿淀粉酶水平低于T1(P＜0.05)，研究组T1、T2血、尿淀粉酶水平均低于对照组(P＜0.05)；③两组T1、T2血清CRP、IL-6、TNF-α水平均较T0明显降低，且T2低于T1(P＜0.05)，研究组T1、T2时血清CRP、IL-6、TNF-α水平均低于对照组(P＜0.05)。结论：奥曲肽辅助十二指肠镜治疗急性水肿型胆源性胰腺炎可提高早期治疗效果，减轻炎症反应。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical effect of octreotide-assisted duodenoscopy on the acute edematous biliary pancre- atitis. Methods: 100 patients with acute edematous biliary pancreatitis were selected and randomly divided into the study group and the control group with 50 cases in each group. Both groups of patients were given fasting, anti infection, nutritional support, enzyme inhibitor therapy, the control group was treated with duodenal endoscopy and the study group was treated with octreotide-assisted duodenoscopy at the same time. The abdominal pain relief time, white blood cells(WBC), temperature recovery time, hemodlastase and urine amylase, changes of serum CRP, IL-6, TNF-α levels before treatment (T0), on the 3rd day after treatment(T1), on the 7th day after treatment(T2) were compared between the two groups. Results: ①The relief time of abdominal pain, WBC, body temperature returned to normal time of study group were all significantly shorter than those of the control group(P<0.05). ②The hemodlastase and urine amylase level at T1, T2 of both groups of patients were significantly lower than those at T0 and hemodlastase and urine amylase level at T2 lower than T1 (P＜0.05). The hemodlastase and urine amylase levels of study group were lower than those of the control group at T1, T2(P＜0.05). ③The serum CRP, IL-6, TNF-α levels in both groups at T1, T2 were significantly lower than at T0 with and T2 lower than T1(P＜0.05), the serum CRP, IL-6, TNF-α levels of study group were lower than those of the control group at T1, T2(P＜0.05). Conclusion: Oc- treotide-assisted duodenoscopy could effectively enhance the early clinical efficacy and relieve the inflammatory response of acute ede- matous biliary pancreatitis patients. |
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