| 蒋瑞冲,王琦伟,徐 敉,许春立,许文杰.抗氧化类维生素血清水平与帕金森病程的相关性[J].现代生物医学进展英文版,2018,(1):95-99. |
| 抗氧化类维生素血清水平与帕金森病程的相关性 |
| Association of Serum Antioxidant Vitamins with the Progression of Parkinson's Disease |
| Received:June 06, 2017 Revised:June 30, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.01.021 |
| 中文关键词: 抗氧化类维生素 氧化应激 帕金森病 |
| 英文关键词: Antioxidant Vitamins Oxidative stress Parkinson's Disease |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：检测帕金森病患者抗氧化类维生素水平，并探讨其与帕金森病程的关系。方法：对2011年6月至2015年6月的62例自发性帕金森病患者及30例健康对照组志愿者血清类胡萝卜素、生育酚、视黄醇水平进行检测，并根据病程不同，将患者分为早期帕金森病与晚期帕金森病，与健康对照组进行比较。同时分析相关抗氧化性维生素和UPDRS运动评分的相关性。结果：血清α-胡萝卜素水平(对照组：0.22±0.09 μ mol/L；早期PD组：0.13±0.09 μmol/L；晚期PD组：0.09±0.04 μmol/L)和β-胡萝卜素水平(对照组：2.44±0.54 μ mol/L；早期PD组：1.66±0.58 μmol/L；晚期PD组：0.80±0.41 μmol/L)在健康对照组、早期PD组、晚期PD组中逐步下降，且均有显著性差异(P<0.001)。并且所有PD患者血清α-胡萝卜素(r=-0.362；P=0.004)和β-胡萝卜素(r=-0.45；P<0.001)水平与UPDRS运动评分呈负相关。结论：PD患者血清α-胡萝卜素和β-胡萝卜素水平均明显下降，并且与病情严重程度相关，低水平血清类胡萝卜素可能与PD的发生和发展过程相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the association of serum antioxidant vitamins with the progression of Parkinson's Disease. Methods: The serum levels of retinol, carotenoids and tocopherols were measured and compared between 62 patients with idiopathic PD and 30 healthy controls enrolled from July 2011 to July 2015. Multiple group comparisons were performed among the early PD, ad- vanced PD and control groups. Correlation analyses were performed between the measured antioxidant vitamins and Unified Parkinson's Disease Rating Scale (UPDRS) motor score. Results: The results showed a gradually decrease of serum α- carotene (Control group: 0.22±0.09 μmol/L, Early PD group: 0.13±0.09 μmol/L, Advanced PD group: 0.80±0.41 μmol/L) and β- carotene (Control group: 2.44±0.54 μmol/L, Early PD group: 1.66±0.58 μmol/L, Advanced PD group: 0.09±0.04 μmol/L), which were statistically signifi- cant (P<0.001). While UPDRS motor scores in PD patients negatively correlated with serum levels of α-carotene (r=-0.362, P=0.004), β-carotene (r=-0.45；P<0.001). Conclusion: Compared with health controls, serum α- carotene and β- carotene are decreased, and related with severity, which indicated that lower serum carotenes may be associated with the pathogenesis as well as progression of PD. |
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