| 周 辉,张国艳,吴镜湘,肖开提·乃斯如拉,王明亮,蔡高杰.帕瑞昔布联合曲马多对胸腔镜下肺叶切除术患者围术期疼痛和炎性因子的影响[J].现代生物医学进展英文版,2017,17(36):7089-7091. |
| 帕瑞昔布联合曲马多对胸腔镜下肺叶切除术患者围术期疼痛和炎性因子的影响 |
| Effects of Parecoxib Combined with Tramadol on the Perioperative Pain and Inflammatory Cytokines of Patients Treated by Thoracoscopic Lobectomy |
| Received:March 05, 2017 Revised:March 30, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.36.020 |
| 中文关键词: 帕瑞昔布 胸腔镜 下肺叶切除术 围术期疼痛 炎性细胞因子 |
| 英文关键词: Parecoxib Thoracoscopy Lower lobectomy Perioperative pain Inflammatory cytokines |
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| 中文摘要: |
| 摘要 目的：探讨帕瑞昔布联合曲马多镇痛对胸腔镜下肺叶切除术患者围术期疼痛和炎性细胞因子的影响。方法：选取我院2013年4月至2016年4月收治的60例胸腔镜下肺叶切除术患者，按照随机数字表法分为A组和B组，每组者30例。A组患者采取帕瑞昔布镇痛；B组患者采取帕瑞昔布联合曲马多镇痛，采用视觉模拟评分(VAS)评价患者术后30 min、8 h、12 h、24 h镇痛效果以及T0(麻醉诱导前)、T1(手术完成)、T2(术后2 h)、T3(术后6 h)、T4(术后24 h)血清IL-6、IL-8水平的变化。结果：术后30 min、8 h、12 h、24 h，A组VAS评分均高于B组同期，差异具有统计学意义(P<0.05)；B组患者T1、T2、T3、T4时血清IL-6、IL-8水平均明显低于A组患者(P＜0.05)，两组血清IL-6、IL-8水平均在T3时刻达到最高值；A组不良反应发生率为13.3%，高于对照组的10.0%，但差异无统计学意义(P>0.05)。结论：帕瑞昔布联合曲马多镇痛可提高镇痛质量，抑制炎症反应。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of parecoxib combined with tramadol on the pain and inflammatory cytokines of patients undergoing thoracoscopic lobectomy. Methods: Sixty patients undergoing thoracoscopic lobectomy from April 2013 to April 2016 were randomly divided into the group A and group B according to the method of random number table, 30 cases in each group. The analgesic effect of parecoxib combined with tramadol was evaluated by visual analogue scale (VAS) at 30 min, 8 h, 12 h and 24 h after surgery, and the serum changes of IL-6 and IL-8 at T0 (before anesthetic induction), T1 (after surgery), T2(2h after surgery), T3 (6h after surgery) and T4 (24h after surgery) were measured. Results: The VAS scores of group A were higher than those of group B at 30min, 8h, 12 h and 24 h after operation (P<0.05). The expression level of serum IL-6 and IL-8 at T1, T2, T3 and T4 of group B were significantly higher than those of group A (P <0.05). The expression of serum IL-6 and IL-8 were the highest in both groups at the time of T3. The incidence of adverse events in group A was 13.3% which was higher than that of the control group (10.0%), but no significant difference was found between two groups(P>0.05). Conclusion: Parecoxib combined with tramadol could improve the analgesic quality and inhibit the inflammatory response. |
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