| 王成立,高 路,王学莉,伏 添,周林裕,胡 骁.纳洛酮联合依达拉奉治疗重症脑梗死的临床疗效及对血浆TNF-α及IL-6水平的影响[J].现代生物医学进展英文版,2017,17(36):7085-7088. |
| 纳洛酮联合依达拉奉治疗重症脑梗死的临床疗效及对血浆TNF-α及IL-6水平的影响 |
| Curative Efficacy of Naloxone Combined with Edaravone in the Treatment of Severe Cerebral Infarction and Its Effects on the Plasma TNF-α and IL-6 Levels |
| Received:March 31, 2017 Revised:April 27, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.36.019 |
| 中文关键词: 重症脑梗死 纳洛酮 依达拉奉 肿瘤坏死因子-α 白介素-6 |
| 英文关键词: Severe cerebral infarction Naloxone Edaravone Tumor necrosis factor-α Interleukin-6 |
| 基金项目:陕西省科技攻关项目（2002K10-G2） |
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| 中文摘要: |
| 摘要 目的：探讨纳洛酮联合依达拉奉治疗重症脑梗死的临床疗效及对血浆肿瘤坏死因子(TNF)-α、白介素(IL-6)水平的影响。方法：选择2014年10月至2016年10月我院接诊的92例重症脑梗死患者，通过随机数表法分为观察组(n=46)和对照组(n=46)。两组均给予降脂、控制血糖、血压、降颅压、维持水电解质、营养脑细胞等常规治疗。对照组在此基础上给予依达拉奉的静脉滴注，剂量30 mg，2次/d；观察组在对照组的基础上给予纳洛酮的静脉滴注，剂量2 mg，1次/d，均连续治疗14 d。比较两组临床疗效及治疗前后血浆TNF-α、IL-6、NIHSS评分、Barthel指数的变化以及不良反应的发生情况。结果：治疗14d后，观察组临床疗效总有效率明显高于对照组(P＜0.05)。与治疗前比较，两组治疗后血浆TNF-α、IL-6水平、NIHSS评分均显著下降(P＜0.05)，Barthel指数明显上升(P＜0.05)，且观察组血浆TNF-α、IL-6水平、NIHSS评分均明显低于对照组(P＜0.05)，Barthel指数显著高于对照组(P＜0.05)。两组治疗过程中均未有严重不良反应发生。结论：纳洛酮联合依达拉奉治疗重症脑梗死患者的临床效果显著，可促进神经功能恢复，且安全性高，可能与其有效降低血浆血浆TNF-α、IL-6水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the curative efficacy of naloxone combined with edaravone in the treatment of severe cerebral in- farction and its effects on the plasma tumor necrosis factor(TNF)-α and interleukin(IL)-6 levels. Methods: 92 patients of severe cerebral infarction who were treated from October 2014 to October 2016 in our hospital were selected. According to random number table, those patients were divided into the observation group (n=46) and the control group (n=46). Both groups were given lipid-lowering therapy, blood glucose control, blood pressure, intracranial pressure, maintenance of water electrolyte, brain cells and other conventional treat- ment. The control group was treated with intravenous infusion of edaravone, a dose of 30 mg, 2 times /d, while the observation group was combined with intravenous infusion of naloxone, a dose of 2 mg, 1 times /d, they were continuously treated for 14 days. The clinical cu- rative effect and the changes of plasma TNF-α, IL-6 levels, NIHSS score and Barthel index before and after treatment and the incidence of adverse reactions were compared between two groups. Results: At 14d after treatment, the total effective rate of observation group was significantly higher than that of the control group(P＜0.05). Compared with before treatment, the plasma TNF-α, IL-6 levels and NIHSS score of both groups were significantly decreased after treatment between the two groups(P＜0.05), while the Barthel index was signifi- cantly incresed(P＜0.05). The plasma TNF-α and IL-6 levels and NIHSS score of observation group were significantly lower than those of the control group(P＜0.05), and the Barthel index was significantly higher than that of the control group(P＜0.05). There were no seri- ous adverse reactions in the two groups. Conclusion: Naloxone combined with edaravone was effective for severe cerebral infarction, which could effectively reduce plasma levels of TNF-α, IL-6, promote the recovery of neurological function with high security. |
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