| 折开娥,樊阳阳,张凌燕,白桂芹,袁晓华.血清hs-CRP、TNF-α和IL-6水平与妊娠高血压的关系[J].现代生物医学进展英文版,2017,17(36):7081-7084. |
| 血清hs-CRP、TNF-α和IL-6水平与妊娠高血压的关系 |
| The Relationship between Serum hs-CRP, TNF-α and IL-6 Levels and Gestational Hypertension |
| Received:July 04, 2017 Revised:July 27, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.36.018 |
| 中文关键词: 孕期 妊娠高血压 高敏C-反应蛋白(hs-CRP) 肿瘤坏死因子-α(TNF-α) 白介素-6(IL-6) |
| 英文关键词: Gestation Gestational hypertension High-sensitivity c-reactive protein (hs-CRP) Tumour necrosis factor-α(TNF-α) Interleukin-6(IL-6) |
| 基金项目:国家自然科学基金项目（81200418） |
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| 中文摘要: |
| 摘要 目的：探讨血清高敏C-反应蛋白(high-sensitivity c-reactive protein, hs-CRP)、肿瘤坏死因子-α(tumour necrosis factor-α, TNF-α)及白介素-6(interleukin-6, IL-6)水平与妊娠高血压的关系。方法：选择2014年1月至2016年12月于我院接受产检并于妊娠期诊断为妊娠期高血压的孕妇129例作为观察组，其中孕早期、孕中期和孕晚期诊断为高血压的孕妇各43例；选择同期在我院接受产检的健康孕妇129例作为对照组，其中孕早期、孕中期和孕晚期的健康孕妇各43例。比较两组血清hs-CRP、TNF-α和IL-6水平。结果：观察组不同孕期的孕妇血清hs-CRP、TNF-α和IL-6水平均显著高于对照组(P<0.05)；两组不同时期的血清hs-CRP和TNF-α水平比较差异无统计学意义(P>0.05)，而孕中期和孕后期的血清IL-6水平高于孕前期(P<0.05)。血清hs-CRP和TNF-α水平与孕周并无明显的相关性(r=0.339，P=0.307；r=0.448，P=0.167)；血清IL-6水平与孕周呈显著正相关(r=0.827，P=0.002)。结论：血清hs-CRP、TNF-α和IL-6水平升高可能与妊娠高血压的发生有关，可为妊娠高血压的诊断提供一定参考依据，为防止妊娠高血压的发生需严格监控孕前期之后孕妇的IL-6水平。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the relationship between serum high-sensitivity c-reactive protein(hs-CRP), tumour necrosis factor-α(TNF-α) and interleukin-6(IL-6) levels and gestational hypertension. Methods: Pregnant women diagnosed with gestational hypertension (129 cases) in our hospital from January 2014 to December 2014 were selected as the observation group, including 43 cases of gestational hypertension during early gestation, mid-gestation and late-gestation respectively. While the healthy pregnant women received antenatal care in our hospital (129 cases) were selected as the control group, including 43 cases of healthy pregnant women during early gestation, mid-gestation and late-gestation respectively. The serum hs-CRP, TNF-α and IL-6 levels of two groups were compared. Results: The serum hs-CRP, TNF-α and IL-6 levels of observation group during different gestation were higher than those of the control group (P<0.05). The serum hs-CRP and TNF-α levels during different gestation of two groups showed no significant difference (P>0.05); the IL-6 level during mid-gestation and late-gestation of two groups were higher than those during early gestation (P<0.05). Gestational age and hs-CRP or TNF-α level showed no obvious correlation (r=0.339, P=0.307; r=0.448, P=0.167); Gestational age was positively correlated with the serum IL-6 level (r=0.827, P=0.002). Conclusion: Elevated levels of serum hs-CRP, TNF-α and IL-6 may be related to the occurrence of gestational hypertension, which may provide a reference for the diagnosis of gestational hypertension. To prevent the occurrence of gestational hypertension, IL-6 levels of pregnant women need to be strictly monitored after pregnancy. |
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