李广博,张淑君,姚 婕,孔珊珊,成秉林.程序性细胞死亡机制的研究进展[J].现代生物医学进展英文版,2017,17(35):6992-6996. |
程序性细胞死亡机制的研究进展 |
New Advance in Mechanisms of Programmed Cell Death |
Received:December 08, 2016 Revised:December 30, 2016 |
DOI:10.13241/j.cnki.pmb.2017.35.045 |
中文关键词: 非程序性细胞死亡 程序性细胞死亡 机制 |
英文关键词: non-programmed cell death programmed cell death mechanism |
基金项目:黑龙江省自然科学基金项目(H201340);黑龙江省教育厅科学技术研究项目(12531317) |
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中文摘要: |
摘要:细胞是生物体最基本的结构单位和功能单位,细胞死亡对于多细胞生物的发育和稳态极为重要,也是生命的基本过程之一。目前认为细胞死亡形式主要分为两大类:非程序性细胞死亡(non-programmed cell death, NPCD)即坏死(necrosis);程序性细胞死亡(programmed cell death, PCD)。PCD与坏死不同,组织内无可见的炎症反应,无死亡细胞的溶解。程序性细胞死亡按其发生机制的不同可以分为凋亡(apoptosis)、自吞噬性程序性细胞死亡(autophagic cell death)、类凋亡/副凋亡(paraptosis)、细胞有丝分裂灾难(mitotic catastrophe)、胀亡(oncosis)、焦亡(pyroptosis)、胞质自切(autoschizis)、细胞程序性坏死(necroptosis)、细胞侵入性死亡(entosis)、铁死亡(ferroptosis)等。近年来,程序性细胞死亡在肿瘤发生发展中的作为成为研究热点,所以对程序性细胞死亡机制的研究至关重要,本文将对各类型程序性细胞死亡的机制做简要综述。 |
英文摘要: |
ABSTRACT: The cell is the basic structural, functional, and biological unit of all known living organisms. Cell death plays a pivotal role for the development of multicellular organism and in maintenance of the steady state in continuously renewing tissues. There are two kinds of cell death, one is non-programmed cell death (NPCD), and the other is programmed cell death (PCD). Programmed cell death, according to the mechanism, can be divided into apoptosis, autophagic cell death, paraptosis, mitotic catastrophe, oncosis, pyroptosis, au- toschizis, necroptosis, entosis, ferroptosis, et al. In recent years, lots of attention has focused on the role of programmed cell death in tu- morigenesis, And this article will make a brief review on the mechanisms of various types of programmed cell death. |
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