| 刘 浩,石青青,刘顺事,吴向阳,高秉仁.干细胞治疗心血管疾病的研究进展[J].现代生物医学进展英文版,2017,17(35):6955-6958. |
| 干细胞治疗心血管疾病的研究进展 |
| Advances in Stem Cell Therapy for Cardiovascular Diseases |
| Received:December 28, 2016 Revised:January 23, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.35.036 |
| 中文关键词: 干细胞 移植 心肌梗死 心脏干细胞 |
| 英文关键词: Stem cell Transplant Myocardial infarction Cardiac stem cells |
| 基金项目:国家自然科学基金项目( 81470026 )；兰州大学中央高校基本科研业务费专项资金资助( lzujbky-2015-47) |
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| 中文摘要: |
| 摘要：干细胞移植能促使受损心肌再生和改善心功能，是治疗心血管疾病的理想选择。现在有多种干细胞用于研究，用于治疗心血管疾病的干细胞包括胚胎干细胞，诱导多能干细胞、骨髓间充质干细胞和心脏干细胞。不同类型的干细胞都有各自的优点和局限性。胚胎干细胞由于伦理问题应用受到限制。诱导多能干细胞具有胚胎样细胞的特性，增殖能力很强，但是有形成肿瘤的风险。间充质干细胞由于具有免疫调节特性可作为万能供体细胞。心脏干细胞比其它类型的干细胞能更好地表达心肌分化的标记物，改善心脏功能。本文对干细胞在心血管疾病研究及治疗中的最新进展进行综述。 |
| 英文摘要: |
| ABSTRACT: The transplantation of stem cells can promote the regeneration of damaged myocardium and improve cardiac function, which is ideal for the treatment of cardiovascular disease. A variety of stem cells can be utilized in the scientific research. The stem cells which are used for the treatment of cardiovascular diseases include embryonic stem cells, induced pluripotent stem cells, bone marrow mesenchymal stem cells and cardiac stem cells. Different types of stem cells have their own advantages and limitations. Embryonic stem cells are limited in their application due to ethical concerns. Induced pluripotent stem cells have the characteristics of embryonic-like cells, and have a strong ability to proliferate, but there is the risk of tumor formation. Mesenchymal stem cells can be used as universal donor cells due to their immunoregulatory properties. Cardiac stem cells can express markers of cardiac differentiation and improve car- diac function better than other types of stem cells. In this paper, the stem cells in cardiovascular disease research and treatment of the latest progress will be summarized. |
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