| 周广杰,何俊豪,赵 健,宋晓峰,韩 平.LncRNA在神经发育及神经性疾病中作用的研究进展[J].现代生物医学进展英文版,2017,17(35):6946-6949. |
| LncRNA在神经发育及神经性疾病中作用的研究进展 |
| Research Progress of LncRNA's Role in Neural Development and Nervous Diseases |
| Received:December 23, 2016 Revised:January 18, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.35.034 |
| 中文关键词: lncRNAs 神经干细胞 神经发育 神经性疾病 |
| 英文关键词: LncRNAs Neural stem cells Neural development Nervous diseases |
| 基金项目:国家自然科学基金项目（81270700，61571223） |
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| 中文摘要: |
| 摘要：长链非编码RNA (long non-coding RNA , lncRNA)是指不具有编码蛋白能力且长度大于200nt的RNA，近年来，越来越多的lncRNAs在多种生命活动中发挥着重要的作用。已有研究发现lncRNAs在神经发育过程中起着重要的作用，lncRNAs可以调控神经干细胞定向分化为神经元、胶质细胞、星状细胞，lncRNAs，还参与调控神经干细胞的分化进程；lncRNAs表达异常与神经疾病也有密切关系。本文就lncRNAs在调控神经细胞分化进程和在神经性疾病作用的研究新进展进行综述。 |
| 英文摘要: |
| ABSTRACT: Long non-coding RNAs (lncRNAs) refer to a group of RNAs whose lengths are more than 200nt and have no ability to encode protein. In recent years, more and more lncRNAs play important roles in many kinds of life activities. Studies have found that lncRNAs play important roles in neural development process, lncRNAs can regulate neural stem cell to neurons, glial cells, stellate cells, lncRNAs are also involved in neural stem cell differentiation process; lncRNAs expression abnormalities are also closely related with many neurological diseases. In this paper, we reviewed the new progress of lncRNAs in the regulation of neural cell differentiation and the roles in nervous diseases. |
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