| 周 瑜,刘珊珊,张珏颢,吴 宇,宿明艳,周路阳.顺式阿曲库铵与维库溴铵用于乳腺癌改良根治术患者的麻醉效果及对诱导期应激反应的影响[J].现代生物医学进展英文版,2017,17(35):6869-6872. |
| 顺式阿曲库铵与维库溴铵用于乳腺癌改良根治术患者的麻醉效果及对诱导期应激反应的影响 |
| Effects of Sequential Atracurium and Rocuronium on the Patients Undergoing Modified Radical Mastectomy for Breast Cancer and Stress Response during Induction Period |
| Received:August 07, 2017 Revised:August 30, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.35.016 |
| 中文关键词: 顺式阿曲库铵 维库溴铵 乳腺癌改良根治术 麻醉效果 应激反应 |
| 英文关键词: Atracurium Rocuronium Modified radical mastectomy Anesthesia effect Stress response |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：研究顺式阿曲库铵与维库溴铵用于乳腺癌改良根治术患者的麻醉效果及对诱导期应激反应的影响。方法：选择2015年1月～2016年12月于我院采用乳腺癌改良根治术进行治疗的78例患者，随机分为两组。对照组患者给予顺式阿曲库铵进行麻醉诱导，研究组患者给予维库溴铵进行麻醉诱导。比较两组的麻醉效果，麻醉诱导前(T0)、麻醉诱导后(T1)、插入气管导管后3 min(T2)的脉搏血氧饱和度、平均动脉压、心率、血清去甲肾上腺素以及肾上腺素水平的变化情况，术后肌肉颤抖以及恶心呕吐等不良反应的发生情况。结果：研究组的麻药维持时间以及气管拔管时间均明显长于对照组(P<0.05)，麻药起效时间明显短于对照组(P<0.05)。在T0时，两组的脉搏血氧饱和度、平均动脉压、心率、血清去甲肾上腺素以及肾上腺素水平相比差异均无统计学差异(P>0.05)。在T1及T2时，研究组的脉搏血氧饱和度明显高于对照组，而平均动脉压、心率、血清去甲肾上腺素以及肾上腺素水平均显著低于对照组(P<0.05)。研究组不良反应的发生率为10.25%，明显低于对照组的25.64%(P<0.05)。结论：维库溴铵对乳腺癌改良根治术患者的麻醉效果明显优于顺式阿曲库铵，对血流动力学以及应激反应的影响程度更轻，且起效迅速，安全性更高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of sequential atracurium and rocuronium on the patients undergoing modified rad- ical mastectomy for breast cancer and stress response during the induction period. Methods: 78 cases of patients undergoing modified radical mastectomy for breast cancer in our hospital from January 2015 to December 2016 were selected and randomly divided into two groups. Patients in the control group were given induction of atracurium, and the study group was induced by rocuronium. The anesthetic effect, the change of pulse oxygen saturation at preinduction (T0), post-anesthesia(T1), After the tracheal tube inserted for 3 min(T2), the mean arterial pressure and heart rate, noradrenaline changed situation and adrenaline levels, and the incidence were compared between two groups. Results: The anesthetic maintenance time and extubation time of study group were significantly longer than those of the con- trol group (P<0.05), and the onset time of anesthesia was significantly shorter than that of the control group (P<0.05); at T0, there was no significant difference in the pulse oximetry, mean arterial pressure, and heart rate, serum norepinephrine and epinephrine levels between the two groups (P>0.05), at T1 and T2, the saturation of pulse oximetry of study group were higher than those of the control group, the av- erage arterial pressure(P<0.05), the heart rate, serum norepinephrine and epinephrine levels were lower than those of the control group(P<0.05), the incidence of side effects in the study group was 10.25%, which was significantly lower than that of the control group (25.64%, P<0.05). Conclusion: The anesthetic effect of Rocuronium on breast cancer patients was significantly better than cisatracuri- um, which showed less impact on the hemodynamics and stress reaction with rapider onset. |
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