| 张春霞,王继春,陈柏谕,宋冬梅,多红英.曲普瑞林对特发性中枢性性早熟女童血清P1NP、β-CTX、N-MID的影响[J].现代生物医学进展英文版,2017,17(35):6856-6859. |
| 曲普瑞林对特发性中枢性性早熟女童血清P1NP、β-CTX、N-MID的影响 |
| Effect of Triptorelin on Serum Levels of P1NP, β-CTX and N-MID in Children with Idiopathic Central Precocious Puberty |
| Received:June 26, 2017 Revised:July 15, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.35.013 |
| 中文关键词: 醋酸曲普瑞林 特发性中枢性早熟 治疗效果 |
| 英文关键词: Triptorelin Idiopathic central precocious puberty Clinical effect |
| 基金项目:内蒙古自然科学基金项目(2006DB139) |
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| 中文摘要: |
| 摘要 目的：研究匹多曲普瑞林对特发性中枢性性早熟女童的P1NP、β-CTX、N-MID的影响。方法：研究对象选取我院2015年6月到2016年12月期间收治的特发性中枢性性早熟女童138例，按照随机数表法将其分为观察组和对照组，每组69例。对照组患儿接受利甲地孕酮治疗，观察组患儿接受曲普瑞林治疗。比较两组患儿的治疗总有效率，不良反应发生率和治疗前后的血清P1NP、β-CTX、N-MID水平。结果：观察组的治疗总有效率高于对照组(x2=4.10,P=0.04 )；治疗前，两组患儿的血清P1NP、β-CTX、N-MID水平比较均无明显差异(P>0.05)。治疗后，两组患儿血清P1NP、N-MID水平均明显低于治疗前，β-CTX水平明显高于治疗前(P<0.05)。治疗后，观察组患儿的血清P1NP、N-MID水平均明显低于对照组，β-CTX水平高于对照组(P<0.01)；观察组激素样改变、胃肠道反应、神经系统等不良反应发生率低于对照组(x2=7.51,P=0.01)。结论：曲普瑞林治疗特发性中枢性早熟的临床疗效显著，安全性高，能够降低患儿性激素水平，改善骨骼发育，提高远期预后，具有临床推广价值。 |
| 英文摘要: |
| ABSTRACT Objective: To study the effect of triptorelin on serum levels of P1NP, β-CTX and N-MID in children with idiopathic central precocious puberty. Methods: 138 children with idiopathic central precocious puberty who were treated in our hospital from June 2015 to December 2016 were selected and randomly divided into the observation group and the control group, with 69 cases in each group. The patients in the control group were treated with megestrol, while the patients in the observation group were treated with trip- torelin. Then the total effective rate, adverse reactions and serum levels of P1NP, β-CTX and N-MID in the two groups were observed and compared before and after the treatment. Results: The total effective rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant (x2=4.10, P=0.04). After treatment, the serum levels of P1NP and N-MID in the observation group were significantly higher than those of the control group, while the serum levels of β-CTX in the obser- vation group was significantly lower than that of the control group, and the differences were statistically significant (P<0.01). The adverse reaction rate of the observation group was significantly lower than that of the control group, and the difference was statistically significant(x2=7.51, P=0.01). Conclusion: The clinical efficacy of triptorelin on idiopathic central precocious puberty is significant and safe, which can reduce the levels of sex hormones and improve the development of bones, as well as promote the long-term prognosis, and it is wor- thy of clinical application. |
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