| 薛 娜,吴 丽,吴献伟,赵 欣,王志华.丙泊酚与右美托咪定对食管癌根治术患者氧合指数及COR、CRP水平的影响比较[J].现代生物医学进展英文版,2017,17(33):6523-6526. |
| 丙泊酚与右美托咪定对食管癌根治术患者氧合指数及COR、CRP水平的影响比较 |
| Comparison of the Effects of Propofol and Dexmedetomidine on the Oxygenation Index and Serum COR, CRP Levels of Patients Undergoing Radical Resection of Esophageal Carcinoma |
| Received:April 29, 2017 Revised:May 23, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.33.028 |
| 中文关键词: 丙泊酚 右美托咪定 食管癌根治术 氧合指数 应激反应 |
| 英文关键词: Propofol Dexmedetomidine Radical resection of esophageal carcinoma Oxygenation index Stress response |
| 基金项目:陕西省自然科学基金项目（09KH1483） |
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| 中文摘要: |
| 摘要 目的：比较丙泊酚与右美托咪定对食管癌根治术患者氧合指数及皮质醇(COR)、C反应蛋白(CRP)水平的影响。方法：研究对象选择2013年8月~2016年8月择期行食管癌根治术患者，性别不限，96例，根据其入院顺序的不同分成两组，奇数为观察组(n=48)，偶数为对照组(n=48)。比较两组手术情况及肺部并发症的发生情况，并于麻醉前(T0)、切皮后2h(T1)、术后24h(T2)抽动脉血进行血气分析，计算出氧合指数(OI)，同时采集外周静脉血检测血清COR、CRP水平。结果：两组手术时间、术中失血量、术中补液量、术后清醒时间比较差异均无统计学意义(P>0.05)。两组T1、T2时点OI值明显低于T0时点(P<0.01)，但观察组T1、T2时点OI值明显高于对照组同时点(P<0.01)。两组T1、T2时点COR、CRP水平逐渐升高，且均显著高于T0时点(P<0.01)；观察组T2时点COR、CRP水平显著低于对照组同时点(P<0.01)。两组各项肺部并发症的发生率比较差异无统计学意义(P>0.05)。结论：右美托咪定相对于丙泊酚能有效减轻食管癌根治术引起的肺氧合功能下降及手术产生的应激反应。 |
| 英文摘要: |
| ABSTRACT Objective: To compare the effects of propofol and dexmedetomidine on the oxygenation index, serum cortisol (COR) and C reactive protein (CRP) levels of patients undergoing radical resection of esophageal carcinoma. Methods: 96 cases of patients con- ducted radical resection of esophageal carcinoma in our hospital from February 2016 to March 2017 and were selected and divided into the following groups according to the order of admission, the observation group with odd numbers (n=48) and the control group with even numbers (n=48). Then the operation and incidence of complications of the two groups were compared, and the blood gas analysis was performed to calculate the oxygenation index (OI) respectively before the anaesthesia (T0), at 2 hours after the skin incision (T1) and at 24 hours after the operation (T2). At the same time, peripheral venous blood was collected to detect the levels of serum COR and CRP. Results: There was no significant difference between the two groups in the operation time, intraoperative blood loss, intraoperative fluid supply and postoperative awake time (P>0.05). The OI value of both groups at T1 and T2 were significantly lower than those at T0 (P<0.01). The OI value of T1 and T2 in observation group were significantly higher than those of the control group at the same time point (P<0.01). The serum COR and CRP levels of both groups were gradually increased at T1 and T2, and were significantly higher than that at T0 (P<0.01); the serum COR and CRP levels of observation group were significantly lower than that of the control group at T2 (P<0.01). There was no significant difference in the incidence of pulmonary complications between the two groups (P>0.05). Conclusion: Compared with propofol, dexmedetomidine could effectively reduce the decrease of lung function and the stress response caused by radi- cal resection of esophageal carcinoma. |
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