| 甘 露,陈 燕,邹清靖,刘 华,居文惠,韦 琼.左炔诺孕酮对子宫内膜异位症患者血清TNF-α、IL-6、以及VEGF水平的影响[J].现代生物医学进展英文版,2017,17(33):6510-6513. |
| 左炔诺孕酮对子宫内膜异位症患者血清TNF-α、IL-6、以及VEGF水平的影响 |
| Effects of Levonorgestrel on Serum Levels of TNF-α, IL-6 and VEGF of Patients with Endometriosis |
| Received:May 30, 2017 Revised:June 23, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.33.025 |
| 中文关键词: 左炔诺孕酮 子宫内膜异位症 肿瘤坏死因子-α 白细胞介素-6 血管内皮生长因子 疗效 |
| 英文关键词: Levonorgestrel Endometriosis Tumor necrosis factor-α Interleukin-6 Vascular endothelial growth factor Efficacy |
| 基金项目:湖北省自然科学基金项目(2014-137) |
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| 中文摘要: |
| 摘要 目的：研究左炔诺孕酮治疗子宫内膜异位症患者的临床疗效以及对患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、血管内皮生长因子(VEGF)水平的影响。方法：研究对象选取我院2016年4月到2017年1月间收治的子宫内膜异位症患者94例，采用随机数字法将其分为对照组和研究组，每组各47例。对照组患者于月经第1 d起口服孕三烯酮胶囊治疗，研究组于月经来潮后4d内置入左炔诺孕酮宫内缓释系统(LNG-IUS)治疗，所有患者均连续治疗5个月。比较两组患者的临床疗效、不良反应发生情况及治疗前后血清TNF-α、IL-6、以及VEGF水平的变化。结果：研究组治疗总有效率高于对照组(P=0.03)；治疗后两组患者血清TNF-α、IL-6、VEGF水平均较治疗前明显降低(P<0.05)，且研究组的血清TNF-α、IL-6、VEGF水平均显著低于对照组(P<0.05)；研究组不良反应发生率低于对照组(P=0.04)。结论：左炔诺孕酮治疗子宫内膜异位症的临床疗效显著，治疗安全性较高，可能与有效降低患者血清TNF-α、IL-6及VEGF水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the efficacy of levonorgestrel in the treatment of endometriosis patients and the effect on the serum TNF-α, interleukin-6 (IL-6), vascular endothelial growth factor (VEGF) levels. Methods: A total of 94 patients with endometriosis ad- mitted in our hospital from April 2016 to January 2017 were randomly divided into the control group and the study group (n=47) by ran- dom number method. The patients in control group were treated with gemcitadenone capsules on the first day of menstruation. The pa- tients in study group were treated with levonorgestrel intrauterine sustained release system (LNG-IUS) at 4 days after menstrual cramps. All patients were treated for 5 months. the clinical efficacy and incidence of adverse reactions, serum levels of TNF-α, IL-6 and VEGF before and after treatment were compared between the two groups. Results: The total effective rate was significantly higher in the study group than that of the control group (P=0.03). After treatment, with the serum TNF-α, IL-6 and VEGF levels were significantly de- creased than those before treatment(P<0.05), and the levels of serum TNF-α, IL-6 and VEGF levels in study group were significantly lower than those of the control group (P<0.05). The incidence of adverse reactions in study group was significantly lower than that of the control group (P=0.04). Conclusion: Levonorgestrel can enhance the clinical efficacy in the treatment of EMS patients with high safety, which may be related to the reduce of serum TNF-α, IL-6 and VEGF levels. |
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