| 林 琳,唐 农,刘布谷,张以昆,莫霄云,何贵新.小剂量多巴胺联合米力农对顽固性心力衰竭的疗效及对心功能的影响[J].现代生物医学进展英文版,2017,17(33):6498-6501. |
| 小剂量多巴胺联合米力农对顽固性心力衰竭的疗效及对心功能的影响 |
| Intractable Heart Failure: Efficacy of Low Dose Dopamine Combined with Milrinone and Its Influence on Heart Function |
| Received:March 29, 2017 Revised:April 24, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.33.022 |
| 中文关键词: 多巴胺 米力农 顽固性心力衰竭 心功能 |
| 英文关键词: Dopamine Milrinone Intractable heart failure Heart function |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨小剂量多巴胺联合米力农对顽固性心力衰竭的疗效及对心功能的影响。方法：选取2014年7月-2016年7月我院老年病科、心血管科二区收治的顽固性心力衰竭患者160例，给予常规抗心衰治疗的80例记为对照组，在对照组基础上加用小剂量多巴胺联合米力农治疗的80例记为观察组，疗程均为7 d。比较两组患者的疗效；比较两组患者的左心室射血分数（LVEF）、左室舒张末期内径（LVEDD）、肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）；比较两组患者治疗前后血清NT-proBNP 水平。结果：观察组总有效率为96.25%，显著高于对照组的66.25%（P<0.05）；治疗前两组LVEF、LVEDD、CK、CK-MB比较，差异无统计学意义（P＞0.05）。观察组治疗后的LVEF较对照组升高，LVEDD、CK、CK-MB较对照组降低（P＜0.05）；治疗前两组患者血清NT-proBNP水平无显著差异（P>0.05）。经过治疗后，两组患者血清NT-proBNP水平显著下降（P<0.05），治疗后观察组血清NT-proBNP水平显著低于对照组，差异有统计学意义（P<0.05）。结论：小剂量多巴胺联合米力农治疗顽固性心力衰竭疗效显著，有助于心功能的恢复，显著降低患者血清NT-proBNP水平，值得临床应用。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the efficacy of low dose dopamine combined with milrinone in the treatment of patients with in- tractable heart failure and its influence on heart function. Methods: A total of 160 patients with intractable heart failure,who were treated in First Affiliated Hospital of Guangxi University of Chinese Medicine from July 2014 to July 2016, were selected and divided into con- trol group(n=80) and observation group(n=80). The control group was treated with conventional anti heart failure therapy, and the obser- vation group was added low dose dopamine combined with milrinone on the basis of control group's therapy. The course of treatment was 7 d. The clinical efficacy,the left ventriculai ejection fraction(LVEF), left ventricular end diastolic diameter(LVEDD), creatine kinase(CK), creatine kinase isoenzym(CK-MB), and the serum NT-proBNP levels before and after treatment were compared between the two groups. Results: The total effective rate(96.25%) of the observation group was higher than that(66.25%) of the control group (P<0.05). There were no significant differences in the levels of LVEF, LVEDD, CK, and CK-MB between the two groups before treatment(P>0.05).After the treatment,the level of LVEF in the observation group was higher than that in the control group, while the levels of LVEDD, CK, CK-MB were lower than those in the control group(P<0.05). There was no significant difference in the levels of serum NT-proBNP between the two groups before treatment(P>0.05). The levels of serum NT-proBNP were significantly decreased in the two groups after treatment(P<0.05), and the level of serum NT-proBNP in the observation group was lower than that in the control group, the difference was statistically significant(P<0.05). Conclusion: A small dose of dopamine combined with milrinone is effective in the treatment of in- tractable heart failure. It is helpful to the recovery of cardiac function and can significantly reduce the level of serum NT-proBNP, which is worthy of clinical application. |
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