| 高大志,许 健,史东宏,杨 涛,刘 丽,陈 波.重组人血管内皮抑制素联合肝动脉化疗栓塞治疗肝癌患者的疗效及对VEGF和HIF-1α水平的影响[J].现代生物医学进展英文版,2017,17(33):6478-6482. |
| 重组人血管内皮抑制素联合肝动脉化疗栓塞治疗肝癌患者的疗效及对VEGF和HIF-1α水平的影响 |
| Liver Cancer: Curative Effect of Recombinant Human Endostatin Combined with Transcatheter Arterial Chemoembolization |
| Received:July 02, 2017 Revised:July 26, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.33.017 |
| 中文关键词: 重组人血管内皮抑制素 肝动脉化疗栓塞 肝癌 疗效 VEGF HIF-1α |
| 英文关键词: Recombinant human endostatin Transcatheter arterial chemoembolization Liver cancer Curative effect VEGF HIF-1α |
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| 中文摘要: |
| 摘要 目的：研究重组人血管内皮抑制素（RHE）联合肝动脉化疗栓塞术（TACE）治疗肝癌患者的疗效及对血管内皮生长因子（VEGF）和乏氧诱导因子-1α（HIF-1α）水平的影响。方法：选择从2015年1月到2016年9月在我院接受治疗的肝癌患者92例纳入本次研究，根据随机数字表法将患者分为观察组及对照组各46例，观察组患者应用RHE及TACE联合治疗，对照组仅实施TACE治疗，对比两组总有效率、疗效相关指标以及并发症情况，检测并对比两组治疗前及治疗7d后的VEGF和HIF-1α水平，并采用Spearman法分析VEGF和HIF-1α的相关性。结果：观察组的总有效率为78.26%，较对照组的58.70%明显更高，差异有统计学意义（P＜0.05）。治疗后观察组的肿瘤直径较对照组明显更小，KPS评分较对照组明显更高，差异均有统计学意义（均P＜0.05）。两组治疗后的肿瘤直径较治疗前明显更小，KPS评分较治疗前明显更高，差异均有统计学意义（均P＜0.05）。治疗后观察组的VEGF及HIF-1α水平较对照组明显更低，差异均有统计学意义（均P＜0.05）。两组治疗后的VEGF及HIF-1α水平均较治疗前明显更低，差异均有统计学意义（均P＜0.05）。经Spearman法分析相关性后发现，患者的VEGF和HIF-1α水平呈正相关（P＜0.05）。观察组的并发症总发生率为28.26%，与对照组的19.57%相比，差异无统计学意义（P＞0.05）。结论：应用RHE联合TACE治疗能够明显提升肝癌患者的治疗疗效，还可明显降低VEGF及HIF-1α水平，且二者之间呈正相关，安全性较好，值得临床推广。 |
| 英文摘要: |
| ABSTRACT Objective: To study the effect of recombinant human endostatin (RHE) combined with transcatheter arterial chemoem- bolization (TACE) in the treatment of patients with liver cancer and its influence on the levels of VEGF and HIF-1α. Methods: A total of 92 patients with liver cancer, who were treated in Nanjing Military General Hospital from January 2015 to September 2016, were selected and randomly divided into observation group(n=46) and the control group(n=46). The observation group was treated with RHE combined with TACE,the control group was only received TACE.The total effective rate, indexes correlated with curative effect and complications were compared between the two groups. The levels of VEGF and HIF-1α in the two groups before treatment and 7 d after treatment were detected and compared, and Spearman method was used to analyze the correlation between VEGF and HIF-1α. Results: The total effec- tive rate(78.26%) of the observation group was higher than that(58.70%) of the control group, the difference was statistically significant (P<0.05). After treatment, the tumor diameter of the observation group was significantly smaller than that of the control group, and the KPS score was significantly higher than that of the control group, the difference was statistically significant (P all<0.05). The diameter of tumor in the two groups after treatment was significantly smaller than before treatment,and the KPS score was significantly higher than that before treatment, the difference was statistically significant (P<0.05). After treatment,the levels of VEGF and HIF-1α in the observa- tion group were significantly lower than those in the control group, and the differences were statistically significant (P all<0.05). The levels of VEGF and HIF-1α in the two groups were significantly lower than those before treatment, and the differences were statistically signif- icant (P all<0.05). The correlation analysis of Spearman method showed that VEGF and HIF-1α were positively related (P<0.05). The to- tal incidence rate of complications in the observation group was 28.26%, and the difference was not statistically significant compared with that(19.57%) in the control group (P>0.05). Conclusion: The application of RHE combined with TACE can significantly enhance the curative effect of patients with liver cancer, and it can significantly reduce VEGF and HIF-1α levels, and there was a positive corre- lation between the two indexes, with good safety, which is worthy of clinical promotion. |
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