| 周文锐,朱敏洁,李 琛,梁兴伦,董迪夷.血清HCY、MMP-9、NT-proBNP水平与老年2型糖尿病大血管病变的相关性研究[J].现代生物医学进展英文版,2017,17(32):6283-6286. |
| 血清HCY、MMP-9、NT-proBNP水平与老年2型糖尿病大血管病变的相关性研究 |
| Relationships between serum HCY, MMP-9, NT-proBNP Levels and Large Vascular Disease of Elderly patients with Type 2 Diabetes Mellitus |
| Received:March 30, 2017 Revised:April 23, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.32.017 |
| 中文关键词: 老年2型糖尿病 同型半胱氨酸(HCY) 金属蛋白酶9(MMP-9) N-端B型钠利尿肽(NT-proBNP) 大血管病变 |
| 英文关键词: Elderly type 2 diabetes mellitus HCY MMP-9 NT-proBNP Large vascular disease |
| 基金项目:同济大学附属杨浦医院院级课题支持项目（Se1201418） |
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| 中文摘要: |
| 摘要 目的：探讨血清同型半胱氨酸(HCY)、金属蛋白酶9(MMP-9)、N-端B型钠利尿肽(NT-proBNP)变化与老年2型糖尿病大血管病变的关系。方法：选取我院2014年5月至2016年5月收治的老年2型糖尿病患者50例，依据大血管病变发生情况将其分为合并大血管病变组(A组，n=25)和未合并大血管病变组(B组，n=25)，另选取同期来我院进行体检的健康人员50例作为对照组，比较三组的一般临床资料、血清HCY、MMP-9、NT-proBNP水平。结果：A组患者的收缩压、舒张压、空腹血糖(FBG)、餐后2h血糖(2hBG)水平均显著高于B组(P<0.05)，高密度脂蛋白胆固醇(HDL-C)水平显著低于B组(P<0.05)，但三组患者的性别、年龄、体质量指数(BMI)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平比较差异均无统计学意义(P>0.05)。A组、B组患者的BMI、收缩压、舒张压、FBG、2hBG、HbA1c、TG、TG、LDL-C水平均显著高于对照组(P<0.05)，LDL-C水平均显著低于对照组(P<0.05)，但三组人员的性别、年龄比较差异均无统计学意义(P>0.05)。A组患者的血清HCY、MMP-9、NT-proBNP水平均显著高于B组(P<0.05)；A组、B组患者的HCY、MMP-9、NT-proBNP水平均显著高于对照组(P<0.05)。结论：血清HCY、 MMP-9、NT-proBNP水平与老年2型糖尿病的大血管病变显著相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationships between serum Homocysteine (HCY), metalloproteinase 9 (MMP-9), N- terminal B type natriuretic peptide (NT-proBNP) levels and the large vascular disease of elderly type 2 diabetes mellitus. Methods: 50 cases of elderly patients with type 2 diabetes mellitus in our hospital from May 2014 to May 2016 were selected and divided into the macrovascular disease group (A group, n=25) and the macrovascular disease group (B group, n=25) according to incidence of vascular disease. These patients were regarded as the diabetes group, another 50 cases of healthy controls in our hospital for physical examination in the same period were selected as the control group, the clinical data, HCY, MMP-9, NT-proBNP levels of the three groups were statistically analyzed. Results: In the diabetic group, the systolic and diastolic blood pressures, Fasting plasma glucose (FBG), postprandial 2H blood glucose (2hBG) of A group were significantly higher than B group (P<0.05), the High density lipoprotein cholesterol (HDL-C) level was significantly lower than B group (P<0.05), but the differences of genders, ages, Body mass index (BMI), glycosylated hemoglobin (HbA1c), total cholesterol (TC), three acyl glycerol (TG), low density lipoprotein cholesterol (LDL-C) levels between the three groups had no statistical significance (P>0.05); In the diabetes group, the BMI, systolic blood pressure and diastolic blood pressure, FBG, 2hBG, HbA1c, TG, TG and LDL-C of A group, B group were significantly higher than the control group (P<0.05), the LDL-C levels were significantly lower than the control group (P<0.05), but the differences of sexes and ages between the three groups had no statistical significance (P>0.05); The HCY, MMP-9, NT-proBNP levels of the A group in the diabetic group was significantly higher than the B group (P<0.05), the HCY, MMP-9 and NT-proBNP levels of the A group and B group were significantly higher than the control group (P<0.05). Conclusion: The serum HCY, MMP-9, NT-proBNP levels were significantly correlated with the large vascular disease of elderly patients with type 2 diabetes mellitus. |
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