| 李 雪,韦 翊,陆红梅,刘铭芳,马宏榛,吴甜甜,高伟华,柴立民.NLRP3炎症小体与自身免疫性疾病的相关性研究进展[J].现代生物医学进展英文版,2017,17(31):6183-6185. |
| NLRP3炎症小体与自身免疫性疾病的相关性研究进展 |
| The Research Progress for the Correlation Between NLRP3 Inflammasome and Autoimmune Disease |
| Received:December 28, 2016 Revised:January 24, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.31.043 |
| 中文关键词: 炎症小体 NLRP3 类风湿关节炎 系统性红斑狼疮 |
| 英文关键词: Inflammasome NLRP3 Rheumatoid arthritis Systemic lupus erythematosus |
| 基金项目:国家自然科学基金项目（81373583） |
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| 中文摘要: |
| 摘要：炎症小体是存在于细胞内由激活自身免疫应答的多种蛋白质组成的复合体，可诱导半胱天冬蛋白酶（caspase）-1自我剪切，caspase-1能够调控白细胞介素（IL）-1β、IL-18的产生，并进而刺激炎症小体的形成和分泌，调控机体的自身免疫应答反应。NLRP3炎症小体属于NOD 样受体家族，是一种胞内模式识别受体，主要存在于巨噬细胞和树突状细胞，发挥激活机体免疫炎症的关键作用。病原相关分子模式及损伤相关分子模式与NLRPs结合,启动固有免疫应答，从而导致自身免疫性疾病的发生和发展。本文通过分析归纳近年来炎症小体与自身免疫性疾病的相关性的研究进展，以期为以炎症小体为作用靶点，防治自身免疫性疾病的研究提供指导。 |
| 英文摘要: |
| ABSTRACT: Inflammasomes is a protein complexes composed by intracellular proteins which contributed to autoimmune response. Inflammasomes induce self-cutting of caspase-1. Caspase-1 regulates the production of interleukin (IL)-1β and IL-18, and then reactive to the formation and secretion of inflammasomes. NLRP3 inflammasome belongs to the NOD-like receptors (NLR) family, as an intracel- lular pattern recognition receptor (PRR), mainly exists in macrophages and dendritic cells, plays key role for activating the inflammatory response. NLRPs recognize the pathogen-associated molecular patterns (PAMPS) and damage-associated molecular patterns (DAMPS), initiate innate immune response, contributed to the pathogenesis of autoimmune disease. We analyzed and generalized the research progress for the correlation between inflammasomes and autoimmune disease in recent years, for provide guidance on the prevention and treatment of autoimmune disease targeted on inflammasomes. |
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