| 蔡智伟,叶燕珍,黄淮滨,杨聪德,刘甲兴.血清BNP浓度变化监测对预测STEMI患者PCI术后预后的预测价值[J].现代生物医学进展英文版,2017,17(31):6170-6174. |
| 血清BNP浓度变化监测对预测STEMI患者PCI术后预后的预测价值 |
| Clinical Value of Changes of Serum BNP Concentration for the Prognostic Prediction of Patients with STEMI after PCI |
| Received:June 20, 2017 Revised:July 16, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.31.040 |
| 中文关键词: 急性ST段抬高型心肌梗死 B型钠尿肽 预后 |
| 英文关键词: Acute ST segment elevation myocardial infarction Type B natriuretic peptide Prognosis |
| 基金项目:福建省自然科学基金项目(2013J01305) |
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| 中文摘要: |
| 摘要 目的：分析血清B型钠尿肽(BNP)浓度变化对急性ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入(PCI)术后预后的预测价值。方法：选取130例发病12 h内行PCI治疗的STEMI患者，通过荧光免疫法测定所有患者治疗前、发病24h、发病1周血清BNP水平，根据发病24 h血清BNP水平将患者分为A(≤100 pg/mL)、B(＜100～400 pg/mL)、C(＞400 pg/mL)三组，比较各组入院时Gensini评分、PCI术后1周左室射血分数(LVEF)、左心室舒张末期容积(LVEDV)、左心室壁运动积分指数(LVWMSI)及术后6个月预后(主要心血管不良事件)情况。结果：A组Gensini评分最低，B组居中，C组Gensini评分最高；C组入院时Gensini评分、CI术后1周LVWMSI、随访6个月再发心肌梗死、心力衰竭、心律失常发生率均显著高于A、B组，B组以上指标均明显高于A组(P＜0.05)；Pearson相关性分析显示患者24 h 血清BNP水平与LVWMSI呈显著正相关(r=0.728，P＜0.01)。结论：血清BNP水平可有效反映STEMI患者PCI术后心功能，对近期不良心血管事件有一定的预测价值。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the clinical value of changes of serum type B natriuretic peptide (BNP) concentration for the prognostic prediction of patients with acute ST segment elevation myocardial infarction (STEMI) after percutaneous coronary interven- tion (PCI). Methods: 130 cases of patients with STEMI treated by PCI within 12h after attack were selected. The serum BNP level was determined by fluorescence immunoassay before treatment, in 24 h after attack and in 1 week after attack. According to the serum BNP level in 24h after attack, the patients were divided into group A(≤100 pg/mL), group B(100~400 pg/mL) and group C(>400 pg/mL). The Gensini score on admission, the left ventricular ejection fraction (LVEF), the left ventricular end diastolic volume (LVEDV) and left ven- tricular wall motion score index (LVWMSI) in 1 week after PCI and the incidence of major adverse cardiovascular events) in 6 months after operation were compared among groups. Results: The Gensini score in group A was the lowest, group B was middle, and Gensini score was highest in group C. The Gensini score on admission, LVWMSI at 1 week after PCI operation, the incidence rate of myocardial infarction, heart failure and arrhythmiaatfollow-up for 6 months in group C were significantly higher than those ingroup A and group B, and the indexes ingroup B were significantly higher than those in group A(P<0.05). Pearson correlation analysis showed that the 24 h serum BNP level of patients was significantly positively correlated with LVWMSI(r=0.728, P<0.01). Conclusion: Serum BNP level can effectively reflect the cardiac function of patients with STEMI after PCI, and it is of certain value in prediction of the recent adverse car- diovascular events. |
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