| 黄雅静,胡晓鹏,吴亚群,罗智勇.隐匿性乳腺癌的诊断和治疗方式分析[J].现代生物医学进展英文版,2017,17(31):6066-6069. |
| 隐匿性乳腺癌的诊断和治疗方式分析 |
| Analysis of the Diagnosis and Treatment for Occult Breast Carcinoma |
| Received:March 22, 2017 Revised:April 17, 2017 |
| DOI：0.13241/j.cnki.pmb.2017.31.015 |
| 中文关键词: 腋窝淋巴结转移 隐匿性乳腺癌 乳房切除 放疗 |
| 英文关键词: Axillary metastasis Occult breast carcinoma Mastectomy Radiotherapy |
| 基金项目:国家自然科学基金项目(81502373) |
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| 中文摘要: |
| 摘要 目的：探讨隐匿性乳腺癌的术前诊断方法和最佳治疗方式。方法：回顾性分析我院2005年1月-2016年5月收治的26例隐匿性乳腺癌患者的临床资料，包括治疗方法和预后情况。结果：26例女性患者，在患侧腋窝淋巴结清扫的基础上，14例行患侧乳房切除术+术后放疗，5例仅行患侧乳房切除术，4例行患侧乳腺外上象限局部切除术+术后放疗，3例患者仅行患侧乳房象限切除术。23例患者行术后化疗，根据激素受体情况决定内分泌治疗及靶向治疗。乳房切除与未切除患者术后局部无复发率(P=0.005)及总生存率(P=0.006)比较差别均有明显统计学意义。术后放疗组与未放疗组局部无复发率比较差异有明显统计学意义(p=0.02)，而总生存率比较差异无明显统计学意义(P=0.11)。结论：隐匿性乳腺癌患者术前需完善乳腺彩超、钼靶及MRI等检查，也可选择乳腺核素显像。在患侧腋窝淋巴结清扫的基础上，患侧全乳切除+局部放疗是更加合适的治疗方式。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the preoperative diagnostic methods and optimal surgical management for occult breast car- cinoma(OBC). Methods: A total of 26 cases of patients diagnosed with OBC based on available criteria were collected including thera- peutic methods and follow-up in the Tongji Hospital, Wuhan, China, from January 2005 to May 2016. A systematic retrospective study was performed. Results: On the basis of ipsilateral axillary lymph node dissection (ALND), 14 cases of patients had ipsilateral mastecto- my and postoperation radiotherapy. 5 cases of patients had ipsilateral mastectomy alone. 4 cases had local excision of the affected side breast, whereas 3 cases only had ipsilateral quadrantectomy. Postoperative chemotherapy was performed in 23 cases of patients. En- docrine therapy and targeted therapy were determined according to hormone receptors status. Comparison of breast resection and non re- section group, postoperative local recurrence rate (p=0.005) and overall survival (p=0.006) were significantly different. Compared with postoperative radiotherapy and non radiotherapy group, local recurrence rate had significant difference (p=0.02), overall survival rates were not significantly different (p=0.11). Conclusion: Besides breast ultrasound, mammography and MRI examinations, breast scinti- mammography with technetium-99m tetrofosmin can also be applied for the diagnosis of OBC. Modified radical mastectomy plus radio- therapy is an optimal choice to achieve better survival compared with quadrantectomy alone based on the ipsilateral ALND. |
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