| 邵明学,吴向起,李小波,朱 灏,田乃亮.血小板/淋巴细胞比值评估急性冠脉综合征冠脉病变严重程度的临床价值[J].现代生物医学进展英文版,2017,17(31):6057-6060. |
| 血小板/淋巴细胞比值评估急性冠脉综合征冠脉病变严重程度的临床价值 |
| Clinical Significance of Platelet-to-Lymphocyte Ratio for the Severity Evaluation of Coronary Artery Disease in Patients with Acute Coronary Syndrome |
| Received:July 27, 2017 Revised:August 21, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.31.013 |
| 中文关键词: 急性冠脉综合征 血小板/淋巴细胞比值 Gensini评分 |
| 英文关键词: Acute coronary syndrome Platelet-to-lymphocyte ratio Gensini score |
| 基金项目:国家自然科学基金项目（81600296） |
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| 中文摘要: |
| 摘要 目的：探讨血小板淋巴细胞比值(platelet-to-lymphocyte ratio，PLR)评估急性冠脉综合征(acute coronary syndrome，ACS)冠脉病变严重程度中的临床价值。方法：回顾性分析2015年3月至2017年3月在南京市第一医院心血管内科行冠脉造影的168例ACS患者的临床资料，其中不稳定型心绞痛(unstable angina，UA) 52例，非ST段抬高型心肌梗死(non-ST-segment elevation myo- cardial infarction，NSTEMI) 54例，ST段抬高型心肌梗死(ST-segment elevation myocardial infarction，STEMI)62例，根据冠脉造影结果进行Gensini评分，采用Spearman相关分析对PLR和Gensini评分进行相关性分析。结果：三组白细胞总数、淋巴细胞计数以及LDL比较差异均有统计学意义(P＜0.05)，STEMI组白细胞总数、淋巴细胞计数明显高于UA组及NSTEMI组，LDL显著低于UA组及NSTEMI组，且NSTEMI组白细胞总数、淋巴细胞计数明显高于UA组，LDL显著低于UA组。此外，NSTEMI和STEMI组PLR和Gensini评分显著均高于UA组(P＜0.05)。Spearman相关性分析显示PLR与Gensini评分呈正相关(r=0.2205，P=0.0114)。多元逐步回归分析结果显示PLR和白细胞总数均是Gensini评分的影响因素。结论：PLR在评估ACS患者冠脉病变严重程度中具有一定的价值，其值越高，冠脉病变越重。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the role of platelet-to-lymphocyte ratio(PLR) in evaluating the severity of coronary lesion in pa- tients with acute coronary syndrome(ACS). Methods: A total of 168 patients with ACS who undergoing coronary angiography in depart- ment of cardiovascular medicine of Nanjing First Hospital were included in this study from March 2015 to March 2017. The severity of coronary artery was evaluated using Gensini score. A Spearman correlation analysis was used for the relationship between PLR and Gensini score. Results: There were significant differences in the white blood cells, lymphocyte and low density lipoprotein between UA, NSTEMI and STEMI groups(P＜0.05). White blood cells and lymphocyte were higher in STEMI group compared to that of UA and NSTEMI, and serum LDL level was significant lower than that of UA and NSTEMI groups. Further analysis showed that white blood cells and lymphocyte in NSTEMI group were significantly higher than UA group, but LDL was lower than UA group. Moreover，the PLR and Gensini score in NSTEMI and STEMI groups were significantly higher than in UA group(P＜0.05). There was a positive significant correlation between PLR and Gensini score (r=0.2205, P=0.0114). Multiple stepwise regression analysis showed that both PLR and white blood cells are influence factors for Gensini score. Conclusion: PLR is significantly related to the severity of coronary lesion. Higher level of PLR indicated more serious artery lesion in patients with ACS. |
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