| 王宁勃,雷华斌,郭艺静,田 刚,任 骞.冠脉PCI治疗后血浆脂蛋白相关磷脂酶A2与基质金属蛋白酶-9水平的变化及临床意义[J].现代生物医学进展英文版,2017,17(30):5959-5962. |
| 冠脉PCI治疗后血浆脂蛋白相关磷脂酶A2与基质金属蛋白酶-9水平的变化及临床意义 |
| Changes and Clinical Significances of Plasma Lipoprotein Associated Phospholipase A2 and Matrix Metalloproteinase -9 in the Patients with Coronary Artery PCI |
| Received:June 06, 2017 Revised:June 30, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.30.036 |
| 中文关键词: 动脉粥样硬化 脂蛋白相关磷脂酶A2 基质金属蛋白酶-9 经皮冠状动脉介入 |
| 英文关键词: Atherosclerosis Lipoprotein associated phospholipase A2 Matrix metalloproteinase -9 Percutaneous coronary intervention |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨冠脉经皮冠状动脉介入(PCI)治疗后血浆脂蛋白相关磷脂酶A2(LP-PLA2)与基质金属蛋白酶-9(MMP-9)水平的变化及其临床意义。方法：选择150例急性冠脉综合征(ACS)患者、128例稳定型心绞痛(SAP)患者及100例健康者分为作为ACS组、SAP组及对照组。比较三组入院时血浆MMP-9、LP-PLA2水平及ACS组经PCI治疗前后血浆MMP-9、LP-PLA2水平的变化。结果：与对照组比较，SAP组与ACS组的血浆MMP-9、LP-PLA2水平均明显增高(P＜0.05)；与SAP组比较，ACS组明显增高(P＜0.05)。与术前比较，ACS组术后血浆MMP-9、LP-PLA2水平明显降低(P＜0.05)。MMP-9与LP-PLA2在ACS组血浆中呈显著正相关(r=0.617，P＜0.05)，在SAP组与对照组中无相关性(P＞0.05)。结论：冠脉病变程度越严重，血浆MMP-9和LP-PLA2水平更高；PCI治疗后冠脉斑块趋于稳定，血浆MMP-9和LP-PLA2水平降低，且二者有相关性，提示MMP-9和LP-PLA2参与冠状动脉粥样硬化的发病与发展，且对预测ACS高危人群及评价疗效有一定的临床价值。 |
| 英文摘要: |
| ABSTRACT Objective: Toanalyze the difference of plasma lipoprotein associated phospholipase A2 (LP-PLA2) and matrix metalloproteinase -9 (MMP-9) levels in patients with different severity of coronary artery disease and the impact of percutaneous coronary intervention (PCI), investigating the role and clinical significance of two inflammatory factors in the occurrence and development of coronary artery disease. Methods: 150 patients with acute coronary syndrome (ACS), 128 patients with stable angina pectoris (SAP) and 100 healthy subjects were divided into ACS group, SAP group and control group.The plasma levels of MMP-9 and LP-PLA2 were compared between the three groups,and changes of plasma MMP-9 and LP-PLA2 levels before and after PCI treatment were compared in the ACS group. Results: Compared with the control group, the plasma MMP-9 and LP-PLA2 levels in the SAP and the ACS group were significantly higher (P < 0.05);and compared with the SAP group, those of the ACS group were significantly higher (P < 0.05).Compared with preoperative, the plasma MMP-9 and LP-PLA2 levels in the ACS group were significantly lower (P < 0.05).There was a significant positive correlation between MMP-9 and LP-PLA2 in the ACS group (r=0.617, P < 0.05),and no correlation in the SAP group and the control group (P > 0.05). Conclusion: Plasma MMP-9 and LP-PLA2 levels may be correlated with the severity of coronary artery disease, which have some clinical values in predicting ACS high risk population and evaluating the curative effect. |
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