| 林 源,高海燕,周 芳,郭亚菊,宋书贤.二甲双胍片联合糖脉康颗粒对2型糖尿病患者血清IL-6、TNF-?琢、CRP、APN水平的影响[J].现代生物医学进展英文版,2017,17(30):5883-5886. |
| 二甲双胍片联合糖脉康颗粒对2型糖尿病患者血清IL-6、TNF-?琢、CRP、APN水平的影响 |
| Effects on Metformin Combined with Tangmaikang Particles on the Serum IL-6, TNF-?琢, CRP and APN Levels of Patients with Type 2 Diabetes Mellitus |
| Received:April 16, 2017 Revised:May 12, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.30.019 |
| 中文关键词: 二甲双胍片 糖脉康颗粒 2型糖尿病 炎性因子 脂联素 |
| 英文关键词: Metformin Tangmaikang particles Type 2 diabetes mellitus Inflammatory factor APN |
| 基金项目:陕西省自然科学基金项目（08120053） |
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| 中文摘要: |
| 摘要 目的：研究二甲双胍片联合糖脉康颗粒对2型糖尿病患者血清白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、脂联素(APN)水平的影响。方法：选择2013年2月至2016年10月在我院接受治疗的2型糖尿病患者130例，按照给药方法不同分为对照组和观察组，对照组采用二甲双胍片治疗，观察组以对照组为基础联合糖脉康治疗。治疗8周后，对比两组患者治疗前后血清IL-6、TNF-α、CRP、APN、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)，空腹血糖(FBC)、餐后2小时血糖(2hPBG)、糖化血红蛋白(HbAlc)、胰岛抵抗指数( HOMA-IR)、胰岛β细胞分泌功能指数(HOMA-IS)和胰岛素敏感指数(ISI)的变化。结果：治疗后，两组患者血清IL-6、TNF-α、CRP、TC、TG、LDL-C，FBC、2hPBC、HbAlc，HOMA-IR均较治疗前均明显降低，而血清APN、HDL-C、HOMA-IS、ISI均明显增高(P<0.05)；与对照组相比，观察组患者血清IL-6、TNF-α、CRP、TC、TG、LDL-C，FBC、2hPBC、HbAlc、HOMA-IR水平均较低(P<0.05)，血清APN、HDL-C，HOMA-IS、ISI水平较高(P<0.05)。结论：二甲双胍片联合糖脉康治疗2型糖尿病患者可有效稳定其血脂血糖，改善胰岛功能，可能与其降低血清IL-6、TNF-α、CRP水平，增加血清APN水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the effects of metformin combined with Tangmaikang particles on the serum IL-6, TNF-α,CRP, APN levels of patients with type 2 diabetes mellitus. Methods: 130 patients with type 2 diabetes mellitus who were treated from February 2013 to October 2016 in our hospital were selected and divided into the control group and the observation group according to the dosing method. The control group was treated with metformin, while the observation group was treated with metformin combined with Tangmaikang particles. At 8 weeks after treatment, the changes of serum IL-6, TNF-α, CRP, APN, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL - C), high density lipoprotein cholesterol (HDL - C), fasting blood sugar (FBC), postprandial 2 hours blood glucose (2 HPBG), glycosylated hemoglobin (HbAlc), index of insulin resistance (HOMA IR), islet beta cells secrete a function index (HOMA - IS) and insulin sensitive index (ISI) were compared between two groups. Results: After treatment, the serum IL- 6, TNF-α, CRP levels, TC, TG, LDL-C, FBC, 2 HPBC, HbAlc, HOMA-IR of both groups of patients were significantly lower, the serum APN level, HDL-C, HOMA-IS, ISI were significantly higher(P < 0.05). Compared with the control group, the serum IL-6, TNF-α, CRP level, TC, TG, LDL-C, FBC, 2 hPBC, HbAlc, HOMA-IR of observation group were lower, the serum APN level, HDL-C, HOMA-IS, the ISI were higher (P < 0.05). Conclusion: Metformin combined Tangmaikang particles in the treatment of type 2 diabetes mellitus, which can effectively stabilize its lipid blood sugar, improve insulin function, which reduces the serum levels of IL - 6, TNF-α and CRP levels, increase the serum APN level. |
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