| 郭清保,李立宏,杨彦龙,马 涛,谢曼丽.微创下置管抽吸液化引流术联合依达拉奉对脑出血患者的疗效分析[J].现代生物医学进展英文版,2017,17(30):5849-5852. |
| 微创下置管抽吸液化引流术联合依达拉奉对脑出血患者的疗效分析 |
| Clinical Effects of Minimally Invasive Catheterized Suction Drainage Combined with Edaravone on Cerebral Hemorrhage |
| Received:April 15, 2017 Revised:May 11, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.30.011 |
| 中文关键词: 依达拉奉 微创置管抽吸液化引流术 脑出血 炎性因子 |
| 英文关键词: Edaravone Minimally invasive catheterized suction drainage Cerebral hemorrhage Inflammatory factor |
| 基金项目:陕西省自然科学基金项目（2014-036） |
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| 中文摘要: |
| 摘要 目的：探讨微创下置管抽吸液化引流术联合依达拉奉对脑出血患者的疗效及血清超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平的影响。方法：研究对象选自我院2015年2月~2016年12月收治的146例脑出血患者，采取随机数字表将其分成两组，每组73例。两组患者均采取微创下置管抽吸液化引流术治疗，观察组联合给予依达拉奉治疗，对比两组疗效及治疗前后血清hs-CRP、IL-6、TNF-α水平变化情况。结果：观察组治疗总有效率高于对照组，差异有统计学意义(P<0.05)。与治疗前相比，治疗后14d两组患者的NIHSS评分、血清hs-CRP、IL-6、TNF-α水平均明显下降，BI指数评分明显上升(P<0.01)；且观察组NIHSS评分、血清hs-CRP、IL-6、TNF-α水平均较对照组明显下降(P<0.01)。结论：在微创下置管抽吸液化引流术治疗基础上联合给予依达拉奉治疗脑出血能有效促进炎症反应的缓解，改善神经功能缺损状况，疗效确切。 |
| 英文摘要: |
| ABSTRACT Objective: To explore clinical effects of minimally invasive catheterized suction drainage combined with edaravone on the patients with cerebral hemorrhage and the serum levels of high sensitivity C reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Methods: 146 patients with cerebral hemorrhage in our hospital from February 2015 to December 2016 were selected as the research objects and randomly divided into two groups with 73 cases in each group. Minimally invasive catheterized suction drainage was given to two groups while edaravone was given to the observation group additionally. The clinical effect and changes of serum hs-CRP, IL-6 and TNF-α levels before and after treatment were compared between two groups. Results: The total effective rate of observation group was significantly higher than that of the control group (P<0.05). Compared with before treatment, the NIHSS scores and serum hs-CRP, IL-6 and TNF-α levels of two groups significantly decreased at 14 d after treatment, while the scores of BI index significantly increased (P<0.01). The NIHSS score and serum hs-CRP, IL-6 and TNF-α levels of observation group were significantly lower than those of the control group (P<0.01). Conclusion: Minimally invasive catheterized suction drainage combined with edaravone effectively enhance the alleviate the inflammatory response and improve the neurological function of patients with cerebral hemorrhage. |
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