| 傅 瑶,王行明,汤瑞玲,徐 芳,范立青.SPANX蛋白的研究进展及其与男性生育力的相关性[J].现代生物医学进展英文版,2017,17(29):5793-5796. |
| SPANX蛋白的研究进展及其与男性生育力的相关性 |
| The Advances of SPANX and Its Correlation with Male Fertility |
| Received:February 05, 2017 Revised:February 27, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.29.045 |
| 中文关键词: SPANX 男性生育力 DNA碎片 |
| 英文关键词: SPANX Male fertility DNA fragmentation |
| 基金项目:国家自然科学基金项目（31472054） |
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| 中文摘要: |
| 摘要：男性不育症病因十分复杂，遗传、环境、内分泌等许多因素都会导致男性不育。而现今临床上多依据精液常规分析对男性不育做出诊断和治疗，但仅依赖精液常规参数存在一定局限性。探寻男性生育力的潜在生物标志分子是当前男性不育的迫切需求。精子X染色体核结合精子蛋白（The sperm protein associated with the nucleus on the X chromosome，SPANX）是在精子中表达的一类小分子蛋白，SPANX蛋白家族基因定位在X染色体上，它随精子的成熟而迁徙，参与精子结构的形成，在精子成熟的不同时期，蛋白定位和蛋白表达均存在差异。在精液参数正常的不育男性和自发弱精症的男性中，SPANX表达下调；同时在活性氧自由基（reactive oxygen species，ROS）阴性的精子中，SPANXC表达降低，在DNA碎片率低的精子中，SPANX表达增高；这些表明SPANX与男性生育力存在一定的相关性，但其与生育力的影响极其相关机制还需要进一步的研究。 |
| 英文摘要: |
| ABSTRACT: The aetiology of male infertility is complicated, multi-factors including genetic, environment and endocrine will lead to male infertility and the conventional analysis of sperm are the base of clinical diagnosis and treatment which is insufficient. The re- search of biomarkers of male infertility is in urgent need. The sperm protein associated with the nucleus on the X chromosome (SPANX) are the protein family express in sperm and the SPANX gene locate on X chromosome and the SPANX immigrate along with the matura- tion of sperm and involved in the formation of sperm structure. During the different episode of sperm maturation, the location and expres- sion of SPANX is different. The SPANX has a significantly lower expression in norm-parameter infertile men and idiopathic astheno- zoospermia. And the expression of SPANX decreases in active oxygen species-negative (ROS-) group, but the SPANX overexpress in the low sperm DNA fragmentation group. The research indicated that SPANX has relevance to male fertility, but the mechanism of the rela- tion needs further research. |
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