| 彭 娟,占金琴,杨 敏,朱 梅,钱婷婷.超声引导下硬化剂聚桂醇治疗肝囊肿的初步应用[J].现代生物医学进展英文版,2017,17(29):5724-5727. |
| 超声引导下硬化剂聚桂醇治疗肝囊肿的初步应用 |
| Preliminary Application of Ultrasound Guided Sclerosing Agent Lauromacrogol in Treatment of Hepatic Cysts |
| Received:February 03, 2017 Revised:February 27, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.29.029 |
| 中文关键词: 肝囊肿 超声 硬化剂 聚桂醇 疗效 |
| 英文关键词: Hepatic cyst Ultrasound Sclerosing agent Lauromacrogol Curative effect |
| 基金项目:云南省卫生科技计划项目（2014NS160） |
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| 中文摘要: |
| 摘要 目的：分析超声引导下硬化剂聚桂醇治疗肝囊肿的临床效果。方法：选择2011年4月~2015年1月我院收治的80例肝囊肿患者作为研究对象，分为对照组、治疗组：对照组36例，接受无水乙醇硬化剂治疗；治疗组44例，接受聚桂醇硬化疗法。测定术前、术后1周、术后6个月两组胆碱酯酶（CHE, cholinesterase）、碱性磷酸酶（ALP, alkaline phosphatase）、天门冬氨酸氨基转移酶（AST, Aspartate aminotransferase）、谷氨酸转氨酶（ALT, Alanine aminotransferas）、总胆红素（TBil, total bilirubin）指标的变化，比较两组治疗效果、治疗不良反应、并发症发生情况、各组住院时间和囊肿闭合时间。结果：①术后1周、术后1个月，B组治疗总有效率均高于A组，但仅术后1周总有效率对比差异有统计学意义（P<0.05），两组术后6个月总有效率相近（P>0.05）；②术后1周，A组ALT、AST上升，与B组对比差异有统计学意义（P<0.05），术后6个月，两组ALT均降低，但对比差异无统计学意义（P>0.05）；③B组腹痛、囊内出血、醉酒样反应、针道出血发生率均低于A组，但仅腹痛、醉酒样反应发生率对比差异有统计学意义（P<0.05）；④B组住院时间、囊肿闭合时间均短于A组（P<0.05）。结论：超声引导下聚桂醇硬化疗法治疗肝囊肿，有效率高，对患者肝功能影响小，患者术后恢复速度快，囊肿闭合时间短，安全性高。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the effect of ultrasound guided sclerosing agent lauromacrogol in the treatment of hepatic cysts. Methods: Eighty patients with hepatic cysts treated in our hospital between April 2011 and January 2015 were selected as study subjects- The subjects were divided into the control group(36 cases) and the treatment group（44 cases）. 36 cases in the control group were treated with anhydrous ethanol sclerosing agent while 44 cases in the treatment group were treated with lauromacrogol sclerotherapy. The cholinesterase (CHE), alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin (TBIL) were determined before operation, at 1week and 6 months after operation. The treatment effect, adverse reactions and complica- tions, hospitalization time and the time of cyst closure were compared between the two groups. Results: ①1 week and 1 month after op- eration, the total effective rate of group B was higher than that of group A, but there only was significant difference at 1 week after opera- tion (P<0.05). At 6 months after operation, the total effective rates in the two groups were similar (P>0.05); ②1 week after operation, ALT and AST in group A increased. Compared with group B, there was significant difference (P<0.05). 6 months after operation, ALT of the two groups decreased (P>0.05); ③The incidence rates of abdominal pain, intracystic hemorrhage, intoxication and needle tract bleed- ing in group B were lower than those in group A, but there only were significant differences in the incidence of abdominal pain and intox- ication (P<0.05); ④The hospitalization time and time of cyst closure of group B was shorter than that of group A (P<0.05). Conclusion: The application of ultrasound guided lauromacrogol sclerotherapy in the treatment of hepatic cysts, the effective rate is high and has little effect on the liver function of patients. Patients can recover quickly. The time of cyst closure is short and the safety is high. |
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