| 卓 越,邱小松,薛 婷,李 丽,金 鑫.IL-6、IL-10联合BISAP评分在重症急性胰腺炎预后评估中的作用研究[J].现代生物医学进展英文版,2017,17(29):5708-5711. |
| IL-6、IL-10联合BISAP评分在重症急性胰腺炎预后评估中的作用研究 |
| Research of IL-6 and IL-10 Combined with BISAP Score in Evaluation of Prognosis in Patients with Severe Acute Pancreatitis |
| Received:March 02, 2017 Revised:March 28, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.29.025 |
| 中文关键词: 重症急性胰腺炎 白细胞介素-6 白细胞介素-10 急性胰腺炎严重程度床边指数 预后 |
| 英文关键词: Severe acute pancreatitis Interleukin-6 Interleukin-10 Bedside index for severity in acute pancreatitis Prognosis |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨白细胞介素-6（IL-6）、白细胞介素-10（IL-10）联合急性胰腺炎严重程度床边指数（BISAP）评分在重症急性胰腺炎（SAP）预后评估中的作用。方法：回顾性分析2013年5月至2016年5月我院收治的131例SAP患者的临床病历资料，患者入院后24h内采用酶联免疫吸附法（ELISA）检测血清IL-6和IL-10水平，并进行BISAP评分，同时以接近IL-6、IL-10、BISAP评分中位数的自然值为界值，比较不同预后（死亡、感染、多器官功能障碍综合征（MODS）、局部并发症）的发生率。结果：死亡、MODS、感染患者血清IL-6水平、BISAP评分高于局部并发症患者，血清IL-10水平低于局部并发症患者（P<0.05）；死亡、MODS患者血清IL-6水平、BISAP评分高于感染患者，血清IL-10水平低于感染患者（P<0.05）；死亡患者血清IL-6水平、BISAP评分高于MODS患者，血清IL-10水平低于MODS患者，差异有统计学意义（P<0.05）。IL-6≥65 μg/L、IL-10＜40 μg/L、BISAP评分≥3分患者死亡、MODS、感染发生率更高，差异有统计学意义（P<0.05）。经Pearson积矩相关分析，IL-6、BISAP评分之间呈正相关关系（r=0.617，P<0.05），IL-6、BISAP评分与IL-10之间呈负相关关系（r=-0.572、-0.611，P<0.05）。结论：IL-6、IL-10、BISAP评分是评估SAP预后的重要指标，IL-6水平、BISAP评分越高、IL-10水平越低，患者预后越差，联合应用的预测价值高，临床可作为参考。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effect of interleukin-6(IL-6), interleukin-10(L-10) combined with acute pancreatitis severity index (BISAP) score in the evaluation of prognosis in patients with severe acute pancreatitis (SAP). Methods: The clinical data of 131 pa- tients with SAP, who were admitted to Affiliated Hospital of Xuzhou Medical University from May 2013 to May 2016, were retrospec- tively analyzed. The levels of serum IL-6 and IL-10 were detected by the enzyme-linked immunosorbent assay (ELISA) within 24 h after admission, and the BISAP score was measured. Taking the natural value of the median of IL-6, IL-10 and BISAP score as the boundary value, the occurrence rates of different prognosis (death, infection, multiple organ dysfunction syndrome (MODS) and local complications) were compared at the same time. Results: The levels of serum IL-6, BISAP score of the patients with death, MODS, and infection were higher than those of the patients with local complications, and the levels of serum IL-10 was lower than those of the patients with local complications (P<0.05). The levels of serum IL-6, BISAP score of the patients with death, MODS were higher than those of the patients with infection, and the levels of serum IL-10 was lower than those of the patients with infection, the difference was statistically significant (P<0.05). The incidence of death, MODS, infection in patients with IL6≥65 μg/L, IL-10<40 μg/L, BISAPscore≥3 was much higher, the difference was statistically significant (P<0.05). By the Pearson product moment correlation analysis, there was a positive correlation be- tween IL-6 and BISAP score (r=0.617, P<0.05), while there was a negative correlation between IL-6 and BISAP score and IL-10 (r=-0.572, -0.611, P<0.05). Conclusion: IL-6, IL-10 and BISAP score are the important indexes to evaluate the prognosis of SAP. The higher the IL-6 level, the higher the BISAP score, the lower the level of IL-10, the worse the prognosis. The predictive value of joint application is high, which can be used as reference in the clinic. |
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