| 昝向阳,向兴刚,蔡 宁,于晓晨,买买江·阿不力孜,依马木·依达依吐拉.乌司他丁对重型颅脑损伤患者脑氧代谢、炎性因子及肾功能的影响[J].现代生物医学进展英文版,2017,17(29):5694-5697. |
| 乌司他丁对重型颅脑损伤患者脑氧代谢、炎性因子及肾功能的影响 |
| Influence of Ulinastatin on the Cerebral Oxygen Metabolism Inflammatory Factors and Renal Function of Patients with Severe Craniocerebral Injury |
| Received:March 12, 2017 Revised:April 08, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.29.021 |
| 中文关键词: 重型颅脑损伤 乌司他丁 脑氧代谢 炎性因子 肾功能 |
| 英文关键词: Severe craniocerebral injury Ulinastatin Cerebral oxygen metabolism Inflammatory factor Renal function |
| 基金项目:新疆维吾尔自治区攻关项目(201528332986) |
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| 中文摘要: |
| 摘要 目的：探讨乌司他丁对重型颅脑损伤(SCCI)对患者脑氧代谢、炎性因子及肾功能的影响。方法：将98例SCCI患者随机分为对照组和观察组，每组患者49例。对照组患者给予常规对症支持治疗，观察组患者在此基础上给予乌司他丁滴注治疗。比较两组治疗前及治疗第3 d、7 d的脑氧代谢(SjvO2、CaO2、A-vDO2和CERO2)、炎性因子(TNF-α、IL-6和IL-10)及肾功能(BUN和Cr)的变化。结果：治疗前，两组患者的SjvO2、CaO2、A-vDO2、CERO2、TNF-α、IL-6、IL-10、BUN和Cr水平比较差异均无统计学意义(P>0.05)；治疗3 d、7 d，观察组患者的SjvO2、CaO2和IL-10水平均显著高于对照组，A-vDO2、CERO2、TNF-α、IL-6、BUN和Cr水平均显著低于对照组，差异显著具统计学意义(P<0.05)。结论：乌司他丁治疗SCCI可有效改善患者的脑氧代谢、肾功能，减轻炎症反应。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the influence of ulinastatin on the cerebral oxygen metabolism inflammatory factors and re- nal function of patients with severe craniocerebral injury. Methods: 98 cases of SCCI patients were randomly divided into the control group (n=49) and the observation group (n=49). The control group was given routine symptomatic treatment, while the observation group was treated with ulinastatin on the basis of control group. The cerebral oxygen metabolism (SjvO2, CaO2, A-vDO2 and CERO2), inflam- matory factors (TNF-α, IL-6 and IL-10) and renal function (BUN and Cr) were compared between the two groups before and at 3 d, 7 d after treatment. Results: No significant difference of SjvO2, CaO2, A-vDO2, CERO2, TNF-α, IL-6, IL-10, BUN and Cr levels between the two groups before treatment (P>0.05). At 3d, 7d after treatment, the levels of SjvO2, CaO2 and IL-10 in the observation group were signif- icantly higher than those in the control group, the levels of A-vDO2, CERO2, TNF-α, IL-6, BUN and Cr were significantly lower than those in the control group(P<0.05). Conclusion: Ulinastatin could effectively improve the cerebral oxygen metabolism and renal function, relieve the inflammatory response in the treatment of SCCI. |
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