| 王宇娟,景 阳,刘 晖,王 冰,王 鑫.氯雷他定联合布地奈德鼻喷剂治疗过敏性鼻炎的疗效及对Th1/Th2细胞因子的影响[J].现代生物医学进展英文版,2017,17(28):5552-5556. |
| 氯雷他定联合布地奈德鼻喷剂治疗过敏性鼻炎的疗效及对Th1/Th2细胞因子的影响 |
| Efficacy of Loratadine Combined with Budesonide Nasal Spray in the Treatment of Allergic Rhinitis and its Effect on Th1/Th2 Cytokines |
| Received:May 16, 2017 Revised:June 10, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.28.035 |
| 中文关键词: 氯雷他定 布地奈德 过敏性鼻炎 免疫功能 |
| 英文关键词: Loratadine Budesonide Allergic rhinitis Immune function |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探究氯雷他定联合布地奈德鼻喷剂治疗过敏性鼻炎的临床疗效及对Th1/Th2细胞因子的影响。方法：选取我院2016年1月至2017年1月收治的过敏性鼻炎患者110例，按随机数字法分为实验组与对照组，两组均为55例。对照组的治疗方法为采用氯雷他定，实验组治疗则在对照组的基础上联合布地奈德鼻喷剂，30 d为一个疗程。对比两组患者治疗30d后的临床疗效、症状缓解时间和不良反应情况，以及治疗前、治疗30 d 后Th1/Th2细胞因子白介素-4(IL-4)、γ-干扰素(IFN-γ)的表达水平。结果：治疗30 d后的总有效率，实验组显著高于对照组(P<0.05)，实验组喷嚏、流涕、鼻痒症状缓解时间显著短于对照组(P<0.05)，两组疲劳感、肠胃不适、头痛、皮疹发生率比较无统计学差异(P>0.05)；治疗30d后两组IL-4表达水平显著低于治疗前(P<0.05)，IFN-γ表达水平显著高于治疗前(P<0.05)，实验组IL-4表达水平显著低于对照组(P<0.05)，IFN-γ表达水平显著高于对照组(P<0.05)。结论：氯雷他定联合布地奈德鼻喷剂治疗过敏性鼻炎疗效较好，可显著改善患者临床症状，增强患者免疫功能，安全性较好，值得临床推广。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical efficacy of loratadine combined with budesonide nasal spray in the treatment of allergic rhinitis and its effect on Th1/Th2 cytokines. Methods: 110 patients with allergic rhinitis treated in our hospital from January 2016 to January 2017 were selected, and they were divided into experimental group and control group according to the random number method, with 55 cases in each group. The control group was treated with loratadine, while the experimental group was treated with budesonide nasal spray on the basis of the control group, and 30 days as a course of treatment.The clinical efficacy, symptom relief time, adverse reactions of 30d after treatment and levels of Th1/Th2 cytokines Interleukin -4 (IL-4) and interferon-γ (IFN-γ) of before treatment and 30d after treatment were compared between the two groups. Results: After treated for 30d, the total effective rate of the experimental group was significantly higher than that of the control group (P<0.05). The remission times of sneezing, runny nose and nasal itching in the experimental group were significantly shorter than those in the control group (P<0.05). There was no significant difference in incidences of feeling of fatigue, gastrointestinal discomfort, headache, erythra between the two groups (P>0.05). After treated for 30d, the IL-4 expression levels of the two groups were significantly lower than before treatment (P<0.05); the expression levels of IFN-γ were significantly higher than that before treatment(P<0.05); and the expression level of IL-4 in the experimental group was significantly lower than that in the control group(P<0.05), while the expression level of IFN-γ was significantly higher than that in the control group(P<0.05). Conclusion: Loratadine combined with budesonide nasal spray is effective in the treatment of allergic rhinitis, which can significantly improve the clinical symptoms, enhance the immune function, and is of good security. It is worthy of clinical promotion. |
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