| 鹿亚平,李 娜,张会明,李 博,李 芳.氨氯地平联合阿托伐他汀钙对高血压合并冠心病的疗效分析[J].现代生物医学进展英文版,2017,17(28):5508-5511. |
| 氨氯地平联合阿托伐他汀钙对高血压合并冠心病的疗效分析 |
| Analysis of Efficacy of Amlodipine Combined with Atorvastatin Calcium in Treatment of Hypertension Complicated with Coronary Heart Disease |
| Received:March 18, 2017 Revised:April 15, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.28.025 |
| 中文关键词: 氨氯地平 阿托伐他汀钙 高血压 冠心病 |
| 英文关键词: Amlodipine Atorvastatin calcium Hypertension Coronary heart disease |
| 基金项目:全军后勤科研计划面上项目(CWS14J070) |
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| 中文摘要: |
| 摘要 目的：研究氨氯地平联合阿托伐他汀钙对高血压合并冠心病的临床疗效，对该方法的安全性和有效性进行评价。方法：选取80例高血压合并冠心病患者，随机分为两组，即对照组和观察组。对照组患者给予阿托伐他汀钙片，观察组患者给予氨氯地平阿托伐他汀钙片。观察并记录两组患者治疗前后的收缩压、舒张压水平，以及心绞痛发生情况，治疗前后检测患者体内TG、TC、LDL-C及HDL-C表达水平。结果：和对照组患者相比，观察组患者降压作用及心绞痛改善作用均显效率显著提高（P＜0.05）；和治疗前相比，两组患者收缩压、舒张压，以及TG、TC、LDL-C表达水平均显著降低，HDL-C表达水平均显著升高（P＜0.05）；和对照组患者相比，观察组患者治疗后收缩压、舒张压，以及TG、TC、LDL-C表达水平降低更显著，HDL-C表达水平升高更显著（P＜0.05）。结论：和单独应用阿托伐他汀钙相比，氨氯地平联合阿托伐他汀钙治疗高血压合并冠心病具有更好的的临床疗效，能有效的控制血压及血脂水平。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical efficacy of amlodipine combined with atorvastatin calcium in the treatment of patients with hypertension complicated with coronary heart disease (CHD) and evaluate the safety and efficacy of the method. Methods: 80 patients with hypertension complicated with coronary heart disease were chosen. They were randomly divided into two groups, namely the control group and the observation group. The control group was treated with atorvastatin calcium tablets and the patients in the observation group were given amlodipine atorvastatin calcium tablets. The levels of systolic and diastolic blood pressure before and after treatment in the two groups, as well as the incidence of angina pectoris of the two groups were observed and recorded. The levels of TG, TC, LDL-C and HDL-C were measured before and after the treatment. Results: Compared with the control group, the antihypertensive effect and the improvement of angina pectoris were significantly improved (P <0.05). Compared with pre-treatment, the systolic blood pressure, diastolic blood pressure and TG, TC, LDL-C expression levels were significantly lower, HDL-C was significantly increased (P <0.05). Compared with the control group, the systolic pressure, diastolic blood pressure, as well as TG, TC, LDL-C expression levels decreased more significantly, HDL-C increased more significantly (P <0.05). Conclusion: Compared with atorvastatin calcium alone, amlodipine combined with atorvastatin calcium in the treatment of hypertension with coronary heart disease has a better clinical efficacy, can effectively control blood pressure and blood lipid levels. |
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