| 孔祥丽,张世俊,李军朝,张 雷,李亚军,欧阳松.MMP-9基因多态性与缺血性脑卒中发病及预后的相关性研究[J].现代生物医学进展英文版,2017,17(28):5489-5492. |
| MMP-9基因多态性与缺血性脑卒中发病及预后的相关性研究 |
| Correlation of MMP - 9 Gene Polymorphism with the Pathogenesis and Prognosis of Patients with Ischemic Stroke |
| Received:May 09, 2016 Revised:June 30, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.28.020 |
| 中文关键词: 缺血性脑卒中 基质金属蛋白酶9 C1562T R279Q 基因多态性 |
| 英文关键词: Ischemic stroke Matrix metalloproteinases 9 C1562T R279Q Gene polymorphism |
| 基金项目:陕西省卫生厅科研基金项目(2010H27)；西安医学院第一附属医院基金项目(XYFY10-14) |
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| 中文摘要: |
| 摘要 目的：研究基质金属蛋白酶9（MMP-9）基因多态性与缺血性脑卒中（IS）发病及预后的相关性，为IS的防治提供新的理论依据。方法：选取治疗的IS患者100例，根据TOAST分型标准分为大动脉粥样硬化型（LAA）组41例，小动脉阻塞型（SAO）组59例，并选取健康体检者40例作为对照组，采用PCR-RFLP法检测各组MMP-9基因C1562T、R279Q多态性，并对IS患者进行3个月的随访，采用Logistic回归分析C1562T、R279Q多态性与IS患者预后的相关性。结果：LAA组、SAO组 MMP-9基因C1562T位点T等位基因、C/T＋T/T基因型频数均高于对照组，差异有统计学意义（P＜0.05）， LAA组、SAO组C1562T位点C等位基因、C/C基因型频数及R279Q位点等位基因和基因型频数与对照组比较差异无统计学意义（P＞0.05）；Logistic回归分析显示，MMP-9 各型别基因与预后无明显相关性（P＞0.05）。结论：MMP-9基因 C1562T的T等位基因是IS发病的穿易感基因之一，但MMP-9基因多态性与IS患者的预后并无明显相关性。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relation of MMP-9 gene polymorphism with the pathogenesis and prognosis of patients with IS, so as to provide a new theoretical basis for IS prevention. Methods: The selected 100 patients were divided into the LAA group (41 cases), and the SAO group (59 cases ) according to TOAST classification standard. Another 40 healthy people was selected as the control group. PCR-RFLP method was applied to detect their MMP-9 gene C1562T and R279Q polymorphism. All patients were followed up for 3 months. Logistic regression model was applied to analyze the relationship betwen C1562T and R279Q polymorphism and prognosis of IS patients. Results: MMP-9 C1562T gene loci alleles T, C/T + T/T genotype frequency in the LAA group and the SAO group were higher than in the control group, and the difference was statistically significant (P < 0.05). C1562T loci alleles C, C/C genotype frequency and R279Q loci alleles and genotypes frequency of LAA group and SAO group had no statistical difference when compared with that of the control group (P>0.05). Multi-factor unconditioned Logistic regression analysis showed that all genetypes of MMP-9 had no obvious correlation with prognosis (P>0.05). Conclusion: MMP-9 C1562T T allele was one of the susceptibility genes to IS, but MMP-9 gene polymorphism had no significant correlation with the prognosis. |
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