| 陶琴琴,赵亚静,卢 英,杨晓明,郑长青.不同剂量易善复治疗肝硬化的疗效及安全性研究[J].现代生物医学进展英文版,2017,17(28):5476-5479. |
| 不同剂量易善复治疗肝硬化的疗效及安全性研究 |
| Research on the Efficacy and Safety of Different Doses of Essentiale in the Treatment of Liver Cirrhosis |
| Received:May 20, 2017 Revised:June 15, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.28.017 |
| 中文关键词: 易善复 肝硬化 不同剂量 肝功能 |
| 英文关键词: Essentiale Liver cirrhosis Different doses Liver function |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨不同剂量的多烯磷脂酰胆碱(易善复)对肝硬化的治疗效果及其安全性。方法：以2016年~2017年在我院就诊的70例单纯肝炎后肝硬化(VC)和酒精性肝硬化(AC)患者为研究对象，采用随机数字表法将其随机分为小剂量组和大剂量组，每组35例。小剂量组予易善复10 mL+5%葡萄糖注射液250 mL静滴，大剂量组予易善复20 mL+5%葡萄糖注射液250 mL静滴。观察两组治疗前后临床症状、血尿常规、肾功能、肝功能指标、腹腔彩超的变化情况。结果：两组患者治疗后肝功能指标谷丙转氨酶(ALT)、白蛋白(ALB)、总胆红素(TBIL)、谷草转氨酶(AST)、碱性磷酸酶(ALP)均较治疗前明显改善(P<0.05)，且大剂量组各项指标水平均明显优于小剂量组(P<0.05)；大剂量组治疗肝硬化的总有效率为88.6%，显著高于小剂量组的(68.6%，P<0.05)。两组治疗过程中均未见明显药物副反应。结论：与小剂量易善复相比，大剂量易善复更能改善单纯肝炎后肝硬化和酒精性肝硬化患者的肝功能，提高药物疗效的同时不增加药物副反应，安全性高。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the efficacy and safety of different doses of Essentiale for patients with liver cirrhosis. Methods: 70 cases patients with viral cirrhosis (VC) and alcoholic cirrhosis(AC) treated in our hospital from 2106 to 2107 were selected and randomly divided into two groups (low dose group and high dose group), 35 cases in each group. The low dose group was given Essentiale 10 mL+5% Glucose Injection 250 mL, and the high dose group was given Essentiale 20 mL+5% Glucose Injection 250 mL. The clinical symptoms, blood routine, renal function, liver function and color Doppler ultrasound were observed and compared between two groups before and after treatment. Results: Compared with before treatment, the hepatic function index including alanine amino transferase (ALT), albumin (ALB), total bilirubin (TBIL), aspartate amino transferase (AST), alkaline phosphatase (ALP) were significantly improved in both groups of patients after treatment (P<0.05). And the level of indicators in high dose group were obviously better than those of the low dose group (P<0.05). The total effective rate of high dose group was 88.6%, which was significantly higher than that of the low dose group (68.6%, P<0.05). There was no abnormal reaction and obvious side effects of hematuria, blood glucose and blood lipid in both groups and no obvious side effects. Conclusion: Different doses of Essentiale had therapeutic effect on patients with liver cirrhosis, and compared with the low dose Essentiale, high dose Essentiale can more effectively improve the liver function of patients with liver cirrhosis, and improve the curative effect without increasing the drug adverse reactions, which is worthy of clinical application. |
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