| 李明程,宿华威,彭战利,马 朕,任玉伟.二甲双胍在II型糖尿病合并肝癌中的研究进展[J].现代生物医学进展英文版,2017,17(27):5392-5395. |
| 二甲双胍在II型糖尿病合并肝癌中的研究进展 |
| The Research Progress of Metformin in Type II Diabetes Mellitus with Liver Cancer |
| Received:March 09, 2017 Revised:April 02, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.27.049 |
| 中文关键词: 肝癌 二甲双胍 II型糖尿病 治疗 |
| 英文关键词: Liver cancer Metformin Type 2 diabetes Therapy |
| 基金项目:教育部春晖计划项目（z201409）；黑龙江省教育厅科研基金项目（12541358） |
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| 中文摘要: |
| 摘要：多年来二甲双胍以其安全性高、价格低及疗效好的优点而广泛应用于临床治疗糖尿病。糖尿病增加了肝癌的罹患率并影响其预后。近年来研究发现二甲双胍在治疗II型糖尿病（T2MD）患者时亦降低了其罹患肝癌的风险，大量研究证明其具有抗癌及协同抗癌作用。现本文对二甲双胍在II型糖尿病患者中对肝癌发生的影响进行探讨，对二甲双胍抑制肿瘤的分子生物学机制进行了介绍，列举了最新的实验研究数据，并对现有临床数据进行分析，对于二甲双胍未来的研究方向提出了预期，对于二甲双胍未来在II型糖尿病患者中肝癌的预防作用进行了简要的总结及未来使用的展望，对于其在II型糖尿病合并肝癌的患者中的治疗作用进行了前瞻性的探讨，为二甲双胍在其他癌症防治中的应用提出了可能性。 |
| 英文摘要: |
| ABSTRACT: As a safe, cheap and effective diabetes drug, metformin has been used for many years. Diabetes increases the risk of liver cancer and affects its prognosis. In recent years, it is found that metformin reduces the pancreatic cancer risk in the treatment of dia- betic patients, a large of experiments also prove that it has anti-cancer and synergistic anticancer effect. This paper focused on the effects of metformin on treatment of II type diabetes, discussed the curative effect on liver cancer, suggested the molecular biology mechanism of inhibiting tumor, listed the latest experiment researches, analyzed the existed clinical data, proposed the further study of anticancer mechanism and clinical treatment. Metformin for a future role in prevention of hepatocellular carcinoma in patients with type II diabetes are briefly summarized and future prospects, which in type II diabetic patients with liver cancer in a prospective study of the effect of treatment. Metformin for application in other cancer prevention also raises possibilities. |
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