| 戴 菁,黄增辉,张硕屏,陆长富,林 戈.体外受精-胚胎移植中完全受精失败的原因分析[J].现代生物医学进展英文版,2017,17(27):5389-5391. |
| 体外受精-胚胎移植中完全受精失败的原因分析 |
| Analysis of the Causes of Total Fertilization Failure in Vitro Fertilization-Embryo Transfer |
| Received:December 06, 2016 Revised:December 29, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.27.048 |
| 中文关键词: 完全受精失败 体外受精 透明带 卵胞浆内单精子注射 |
| 英文关键词: Total fertilization failure In vitro fertilization Zona pellucida Intracytoplasmic sperm injection |
| 基金项目:国家自然科学基金面上项目（312715596） |
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| 中文摘要: |
| 摘要：受精是生命起源至关重要的一个步骤。在辅助生殖的过程中，完全受精失败发生具有其复杂性和不可预见性。受精失败常伴随着一些胞间调控机制异常，其中，可能阻滞在与精子穿越卵冠丘复合体、精子-透明带结合/穿透、精子-卵膜结合、卵子激活、精子去浓缩或原核形成等任一阶段。通过卵胞浆内单精子注射可以避免大部分受精失败现象，但某些患者仍无法成功受精，即使采用辅助人工激活也无法完全避免其发生。对于在辅助生殖过程中完全受精失败患者，结合其卵子成熟情况、精子质量及相关检测结果，在后续周期调整临床方案可有效避免受精失败的再次发生。 |
| 英文摘要: |
| ABSTRACT: Fertilization is a crucial step for origin of life. During Assisted Reproductive Technologies (ART), total fertilization failure is complex and unpredictable. Total fertilization failure may related to some abnormal cellular mechanistic events, such as: any stage of sperm and cumulus-oocyte-complexes penetration, sperm-zona pellucida binding / penetration, sperm-oocyte membrane binding, oocyte activation, sperm discondensation or pronuclear formation. Most of total fertilization failure could be solved by intracytoplasmic sperm injection. But oocytes of some patient still can't fertilize successfully, even though assisted oocyte activation be used. As for total fertilization failure patients in ART, combining the mature of oocyte, sperm quality and some trail to improve clinical protocol in later cy- cle may prevent failure to happen again. |
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