| 胡 娜,姜福玉,张中军,毛洪雅,李 荣,周脉涛.星状神经节阻滞治疗烧伤后应激性溃疡的临床研究[J].现代生物医学进展英文版,2017,17(27):5341-5343. |
| 星状神经节阻滞治疗烧伤后应激性溃疡的临床研究 |
| Clinical Research on the Effect of Stellate Ganglion Block on the Stress Ulcer after Burn Injury |
| Received:March 12, 2017 Revised:March 28, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.27.036 |
| 中文关键词: 星状神经节阻滞 内皮素-1 一氧化氮 烧伤 应激性溃疡 |
| 英文关键词: SGB ET-1 NO Burn Stress ulcer |
| 基金项目:全军医药卫生科研基金项目(12MAO13)；江苏大学医学临床科技发展基金项目(JLY20120134)；江苏省无锡市医院管理中心项目(YGZXM1504) |
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| 中文摘要: |
| 摘要 目的：探讨星状神经节阻滞(stellate ganglion block，SGB)对烧伤所致应激性溃疡的临床疗效及其可能作用机制。方法：选取我院烧伤科收治的烧伤后应激性溃疡出血患者40例，将其随机分为星状神经节阻滞组(SGB组，n=20)和常规治疗组(Control组，n=20)。SGB组进行烧伤规范治疗的同时采用星状神经节阻滞治疗，隔日一次，持续治疗一周；Control组只进行常规烧伤治疗。检测和比较两组患者治疗前后血浆ET-1、NO的含量及治疗后临床症状的改善情况。结果：与Control组相比，SGB组患者治疗后血浆ET-1及NO含量均显著降低(P<0.05)，患者的临床总有效率明显高于Control组(P<0.05)。结论：星状神经节阻滞可有效提高烧伤后应激性溃疡患者的临床疗效，可能与其调节血浆ET-1、NO的含量有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical effects of stellate ganglion block(SGB) on the stress ulcer in burn patients and ex- plore the underlying mechanisms. Methods: 40 patients with burn injury induced stress ulcer were randomized to two groups: SGB group (n=20) and Control group (n=20). SGB group was treated with conventional symptomatic therapy, SGB group underwent SGB every two days for 1 week on the basis of Control group. And the levels of plasma ET-1 and NO were detected using ELISA before and after therapy. And the clinical efficacy of the two groups was observed after the treatment. Results: Compared with the Control group, the levels of plasma ET-1 and NO were markedly lower in the SGB group (P<0.05), while the clinical efficacy was higher(P<0.05). Conclusion: SGB could enhance the clinical efficacy stress ulcer in burn patients, which might be related to the decrease of plasma ET-1 and NO levels. |
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