| 刘文萍,李 静,彭颜晖,刘丽丹,沈静怡,徐佳骏.脑蛋白水解物注射液对老年帕金森患者的疗效分析[J].现代生物医学进展英文版,2017,17(27):5312-5314. |
| 脑蛋白水解物注射液对老年帕金森患者的疗效分析 |
| Analysis of the Efficacy of Brain Protein Hydrolysate Injection in the Treatment of Elderly Patients with Parkinson |
| Received:January 04, 2017 Revised:January 29, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.27.028 |
| 中文关键词: 脑蛋白水解物注射液 帕金森 精神 生活质量 |
| 英文关键词: Brain protein hydrolysate injection Parkinson Mental Quality of life |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨脑蛋白水解物注射液对老年帕金森患者的疗效及安全性。方法：选取120例老年帕金森患者，按随机数字表法分为两组，对照组(57例)给予常规治疗，观察组(63例) 在常规治疗基础之上静脉滴注脑蛋白水解物注射液，观察并记录两组统一帕金森评分量表(UPDRS)评分、SF-36量表评分及治疗期间不良反应的发生情况。结果：治疗前，两组UPDRS评分、SF-36量表各项评分相比均无统计学差异(P>0.05)；治疗后，两组UPDRS各项评分及总分均较治疗前明显降低，且观察组UPDRS各项评分及总分较对照组低(P<0.05)，社会功能、情感职能、精神健康评分明显高于对照组(P<0.05)。治疗期间，对照组发生1例头晕，1例恶心，不良反应率为3.5%；观察组发生2例失眠，1例乏力，1例眩晕，1例恶心，不良反应率为7.9%。两组不良发应率相比差异无统计学意义(P>0.05)。结论：脑蛋白水解物注射液对老年帕金森具有较好的疗效，能够提高患者思维能力，改善精神健康，提高其生活质量，且安全性较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the efficacy and safety of brain protein hydrolysate injection in the treatment of elderly pa- tients with parkinson. Methods: 120 patients with parkinson were selected and randomly divided into two groups. The control group (57 cases) was treated by routine treatment, while the observation group (63 cases) was given brain protein hydrolysate injection on the basis of routine treatment. The UPDRS scores, SF-36 scores and adverse reactions during treatment were observed and recorded. Results: Be- fore treatment, the UPDRS and SF-36 scores of both groups had no significant difference (P>0.05). After treatment, the UPDRS scores of both groups were significantly decreased, and the UPDRS score of observation group was lower than that of the control group(P<0.05). The social function, emotional function, mental health score of observation group were higher than those of the control group(P<0.05). During treatment, 1 cases of dizziness, 1 cases of nausea were found in the control group. The adverse reaction rate was 3.5%. 2 cases of insomnia, 1 cases of fatigue, 1 cases of dizziness and 1 cases of nausea were found in the observation group. The adverse reaction rate was 7.9%. There was no statistical difference in the incidence of adverse reactions between two groups(P>0.05). Conclusion: Brain pro- tein hydrolysate injection had significant effect on the Parkinson. It could improve the patients' thinking ability, mental health and quality of life with high safety. |
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