| 李 鹏,刘 杰,吴红丽,李 兰,刘冬妹.轮状病毒感染性腹泻患儿血清CRP、心肌酶谱、肝功能的检测意义[J].现代生物医学进展英文版,2017,17(27):5302-5304. |
| 轮状病毒感染性腹泻患儿血清CRP、心肌酶谱、肝功能的检测意义 |
| The Significance of Detecting Serum CRP, Myocardial Enzymes, Liver Function Index in Pediatric Patients with Rotavirus Infectious Diarrhea |
| Received:December 07, 2016 Revised:December 29, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.27.025 |
| 中文关键词: 轮状病毒 腹泻 细菌感染 C反应蛋白 心肌酶谱 肝功能 |
| 英文关键词: Rotavirus Diarrhea Bacterial infection CRP Myocardial enzymes, Liver function |
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| 中文摘要: |
| 摘要 目的：探究轮状病毒感染性腹泻患儿血清C反应蛋白（CRP）、心肌酶谱、肝功能指标的检测意义。方法：选择2014年1月～2016年5月我院收治的110例轮状病毒感染致腹泻患儿及同期收治的85例细菌感染性腹泻患儿为研究对象，另外选择20名同期于我院体检的年龄、性别相匹配的健康幼儿为对照。比较三组人群血清C反应蛋白、白介素6、肌钙蛋白(hs-cTnT)、肌酸激酶(CK)、同工酶(CL-MB)、门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)水平的差异及轮状病毒感染致腹泻患儿外损伤的发生情况。结果：轮状病毒感染(RV)组患儿下呼吸道感染、皮疹、心肌损伤以及肝功能损伤的发生率均显著高于细菌感染组(P＜0.05)；RV组和细菌感染组组患儿的血清CRP、IL-6水平均显著高于健康对照组，RV组患儿的上述指标显著低于细菌感染组(P＜0.05)；RV组患者肌钙蛋白(hs-cTnT)、肌酸激酶(CK)、同工酶(CL-MB)、门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)水平均显著高于细菌感染组及健康对照组患儿(P＜0.05)，细菌感染组患儿上述指标与健康对照组比较，差异无统计学意义(P＞0.05)。结论：血清CRP、心肌酶谱、肝功能指标联合检测对于早期轮状病毒感染性腹泻与细菌感染性腹泻的鉴别诊断有一定的参考价值。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the significance of detecting serum CRP, myocardial enzymes, liver function index in pediatric patients with rotavirus infectious diarrhea. Methods: 110 pediatric patients with rotavirus infectious diarrhea and 85 age-matched patients with bacterial infectious diarrhea who were both treated in our hospital from January, 2014 to May, 2016 were enrolled in the present study. Another 20 healthy patients who had physical examination in our hospital were considered as control group. The differences of serum CRP, IL-6, hs-cTnT, CK, CL-MB, AST, ALT level and the incidence of parenteral injury were compared. Results: The incidence rate of lower respiratory tract infectivity, rash, myocardial damage and hepatic injury in RV group were significantly lower than the bacte- rial infectious group (P＜0.05), the level of serum CRP, IL-6 in RV group and bacterial infectious group were significantly higher than the control group, and those of RV group were significantly lower than bacterial infectious group (P＜0.05); the level of hs-cTnT, CK, CL-MB, AST, ALT in RV group were significantly higher than bacterial infectious group and control group (P＜0.05), and those indexes of bacterial infectious group were no significantly differences compared with healthy control (P＞0.05). Conclusion: The combined de- tection of serum CRP, myocardial enzyme and liver function indexes were of certain significance in the early distinguishing diagnosis of bacterial infectious diarrhea from rotavirus infectious diarrhea. |
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