| 岳明明,郑 琳,沙塔娜提·穆罕默德,李 丹,王 芳.补肾活血方剂与曼月乐治疗围绝经期功血的疗效及血清激素水平的改善情况比较[J].现代生物医学进展英文版,2017,17(27):5294-5297. |
| 补肾活血方剂与曼月乐治疗围绝经期功血的疗效及血清激素水平的改善情况比较 |
| Comparison of the Clinical Effects and Improvement of Serum Hormone Levels of Kidney Tonifying and Blood Circulation Recipe and Mirena in the Treatment of Perimenopasual Dysfunctional Uterine Bleeding |
| Received:February 08, 2017 Revised:March 02, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.27.023 |
| 中文关键词: 功能失调性子宫出血 围绝经期 补肾活血方剂 曼月乐 |
| 英文关键词: Dysfunctional uterine bleeding Perimenopausal period Kidney tonifying Mirena |
| 基金项目:新疆维吾尔自治区自然科学基金面上项目（2015211C150） |
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| 中文摘要: |
| 摘要 目的：比较补肾活血方剂与曼月乐治疗围绝经期功血的疗效及血清激素水平的改善情况。方法：选择2013年7月至2016年11月我院妇科收治的围绝经期功血患者92例为研究对象，随机分为A组和B组，每组各46例。A组口服补肾活血方剂，B组宫内放置曼月乐，两组均持续治疗3个周期。观察两组的疗效及不良反应发生率，检测两组的血清激素水平及子宫内膜厚度(ET)、血红蛋白(Hb)水平。血清激素指标包括促卵泡生成素(FSH)、黄体生成素(LH)、孕酮(P)及雌二醇(E2)。结果：两组的总有效率比较差异无统计学意义(P>0.05)。治疗后，两组的血清FSH、LH、E2、P、ET和Hb水平均较治疗前显著降低(P<0.01)，且B血清FSH、LH、E2、P和ET水平均显著低于同期的A组(P<0.01)，两组的Hb水平比较差异无统计学意义(P>0.05)。B组(15.22%)的不良反应发生率显著高于A组(0%)(P<0.01)。结论：补肾活血方剂与曼月乐对围绝经期功血的疗效相当，但曼月乐对血清激素水平及子宫内膜增厚的改善作用更强，补肾活血方剂的安全性更高。 |
| 英文摘要: |
| ABSTRACT Objective: To compare the clinical effects and improvement of serum hormone levels of kidney tonifying and blood circulation recipe and mirena in the treatment of perimenopasual dysfunctional uterine bleeding. Methods: 92 cases of perimenopausal patients with dysfunctional uterine bleeding in our hospital from July 2013 to November 2016 were selected and divided into group A and group B with 46 cases in each group. Group A was orally administered with kidney tonifying and blood circulation recipe, and group B was administered with mirena. Both groups were treated for 3 periods. The efficacy and incidences of adverse effect in two groups were observed. The levels of serum hormones and hemoglobin (Hb), and endometial thickness (ET) were detected in two groups. The indices of serum hormone included follicle-stimulating hormone (FSH), luteinizing hormone (LH), progestone (P) and estradiol (E2). Results: No significant difference was found in the total effective rate between two groups(P>0.05). After treatment, the levels of serum FSH, LH, E2 and P as well as ET and Hb in both groups were all significantly lower than those before treatment(P<0.01), and the levels of serum FSH, LH, E2 and P as well as ET of group B were significantly lower than those of group A (P<0.01), no significant difference in the Hb level between two groups(P>0.05). The incidence of adverse reactions of group B (15.22%) was significantly higher than that of group A(0%) (P<0.01). Conclusion: The kidney tonifying and blood circulation recipe had similar effect as mirena in the treatment of perimenopasual dysfunctional uterine bleeding, while mirena had strong improving effect in serum hormone level and ET, kidney tonifying and blood circulation recipe had higher security. |
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