| 王玉金,申艳红,王洪雷,孙保生,成庆明,杜洪泉,贾爱华.血清TgAb水平在分化型甲状腺癌术后转移复发中的预测价值[J].现代生物医学进展英文版,2017,17(27):5279-5282. |
| 血清TgAb水平在分化型甲状腺癌术后转移复发中的预测价值 |
| Predictive Value of Serum TgAb in Recurrence and Metastasis in Patients with Differentiated Thyroid Carcinoma after Operation |
| Received:March 15, 2017 Revised:April 11, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.27.019 |
| 中文关键词: 血清TgAb 分化型甲状腺癌 转移/复发 预测价值 |
| 英文关键词: Serum TgAb Differentiate thyroid carcinoma Recurrence/metastasis Predictive value |
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| 中文摘要: |
| 摘要 目的：探讨完全切除甲状腺组织后血清甲状腺球蛋白（TG）阴性时，血清抗甲状腺球蛋白抗体（TgAb）对分化型甲状腺癌（DTC）术后复发/转移的预测价值。方法：选择2013年4月-2015年4月我院收治的57例完全切除甲状腺组织，TG阴性且TgAb阳性的DTC患者临床病历资料，并将其分为复发/转移组（20例）和无复发/转移组（37例）。采用放射免疫分析法测定并比较两组患者的血清TG、TgAb水平，分析TgAb对DTC复发/转移诊断的灵敏度、特异度、阳性预测值以及阴性预测值，采用Logistic回归分析DTC复发/转移的独立危险因素。结果：复发/转移组的血清TgAb水平为72~3850 IU/mL，高于无复发/转移组的18~3638 IU/mL，差异有统计学意义（P<0.05）。其中TgAb对DTC复发/转移诊断的灵敏度为85.71%，特异度为83.33%，阳性预测值为75.00%，阴性预测值为90.91%。经Logistic回归分析发现，TgAb水平为100≤TgAb＜204 IU/mL、204≤TgAb≤1000 IU/mL、＞1000 IU/mL是DTC复发/转移的独立危险因素（OR=1.267，2.853，6.791，P<0.05）。结论：TgAb可作为评估完全切除甲状腺组织、TG阴性且TgAb阳性的DTC患者复发/转移的重要指标，其值越高，复发/转移发生的可能性越大。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the predictive value of serum thyroglobulin autoantibody (TgAb) for recurrence / metastasisin of thyroglobulin (TG)-negative and TgAb-positive patients with differentiated thyroid carcinoma(DTC) after thyroid ablation. Methods: The clinical data of 57 patients with DTC, undergoing complete resection of thyroid tissue, TG negative and TgAb positive,who were re- viewed in Liaocheng People's Hospital during April 2013 to April 2015, were selected and divided into recurrence/metastasis group (n=20) and no recurrence/metastasis group (n=37). The TG and TgAb levels in the two groups were detected and compared by the elec- trochemical luminescence method,the sensitivity, specificity, positive predictive value and negative predictive value of TgAb in the diag- nosis of DTC recurrence / metastasis were analyzed; the independent risk factors of DTC recurrence / metastasis were analyzed by Logis- tic regression. Results: The TgAb levels(72~3850 IU/mL) in the recurrence/metastasis group was higher than that(18~3638 IU/mL) in the no recurrence/metastasis group,the difference was statistically significant (P<0.05). The sensitivity, specificity,positive predictive value,negative preictive value of TgAb in the diagnosis of recurrence/metastasis of DTC were 85.71%, 83.33%, 75.00%, 90.91%,respectively.Logistic Regression analysis showed that the 100≤TgAb＜204 IU/mL, 204≤TgAb≤1000IU/mL, and ＞1000IU/mL levels of TgAb were the independent risk factors of rucurrence/metastasis of DTC (OR=1.267, 2.853, 6.791, P<0.05). Conclusion: TgAb can be used as evaluation of an important index of the recurrence/metastasis of patients with DTC when serum thyroglobulin (TG) was negative and TgAb was positive after thyroid ablation. The higher the TgAb levels, the more probability of the recurrence/metastasis. |
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