| 孙 颖,张玉龙,毛文娟,刘 莉,韩月肖.桂龙咳喘宁片联合抗菌药物对肺癌化疗后肺部感染的控制效果[J].现代生物医学进展英文版,2017,17(27):5271-5274. |
| 桂龙咳喘宁片联合抗菌药物对肺癌化疗后肺部感染的控制效果 |
| Effect of Guilong Kechuanning Tablets Combine with Antibiotic Drugs on Pulmonary Infection after Chemotherapy in Patients with Lung Cancer |
| Received:March 29, 2017 Revised:April 26, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.27.017 |
| 中文关键词: 桂龙咳喘宁片 抗菌药物 肺癌 感染 疗效 |
| 英文关键词: Guilong Kechuanning tablets Antibiotic drugs Lung cancer Infection Effect |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨桂龙咳喘宁片联合抗菌药物对肺癌化疗后肺部感染的治疗效果，降低医院肺部感染发生率。方法：选择2013年8月~2015年8月在我院确诊并接受化疗治疗的120例肺癌伴有肺部感染的患者，随机分为对照组（n=60）和实验组（n=60）。对照组患者给予头孢唑肟治疗，实验组在此基础上口服桂龙咳喘宁片，两组患者均持续治疗两周。比较两组治疗前后炎症指标，并观察两组临床疗效、住院时间、退热时间、咳嗽咳痰明显减少时间、肺部啰音消失时间及肺部细菌清除率。结果：实验组总有效率为91.67%，明显高于对照组的73.33%，具有显著性差异（x2=13.121；P=0.004）。治疗前，两组WBC、CRP及NEUT水平比较，差异无统计学意义（P>0.05）；治疗后，两组WBC、CRP及NEUT水平均明显低于治疗前（均P<0.05），且实验组均明显低于对照组（P<0.05）。治疗后实验组患者肺部细菌清除率为99.09%，明显高于对照组的86.94%（x2=54.876，P=0.000）。结论：桂龙咳喘宁片联合抗菌药物能够有效控制肺癌化疗后肺部感染，改善患者临床症状及炎症反应，值得临床上推广使用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Guilong Kechuanning tablets combine with antibiotic drugs on pulmonary infec- tion after chemotherapy in patients with lung cancer, so as to reduce the incidence of pulmonary infection in hospital. Methods: A total of 120 patients with lung cancer complicated with pulmonary infection, who underwent chemotherapy in Baoji Hospital of Traditional Chi- nese Medicine from August 2013 to August 2015, were selected and randomly divided into control group (n=60) and experiment group (n=60).The control group was treated with Ceftizoxime,based on which, the experiment group was added oral Guilong Kechuanning tablets.The course of treatment of the two groups was 2 weeks.Inflammation indicators of the two groups were compared before and after treatment,and the clinical effect,hospitalized time,antifebrile time, time significantly reduced of cough and expectoration, disappearance time of lung rales and the pulmonary bacterial clearance rate were observed between the two groups. Results: The total effective rate(91.67%) of experiment group was significantly higher than that(73.33%) of control group (x2=13.121, P=0.004). Before treatment, there were no significant differences in WBC, CRP and NEUT levels between the two groups (P>0.05);while after treatment, the levels of WBC, CRP and NEUT were all lower than those before treatment in both groups (all P<0.05), and the levels of WBC, CRP and NEUT in the experiment group were lower than those in the control group(P<0.05). After treatment, the bacterial clearance rate (99.09%) of the ex- periment group was significantly higher than that (86.94%) of the control group (x2=54.876, P=0.000). Conclusion: Guilong Kechuanning tablets combined with antibiotic drugs can effectively control the pulmonary infection after chemotherapy in the patients with lung can- cer, and can improve the clinical symptoms and inflammatory reaction, which is worthy of clinical application. |
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