| 吴 豫,刘 榕,金建平.类肌钙蛋白（Calponin）亚型和生物学功能 [J].现代生物医学进展英文版,2017,17(26):5185-5188. |
| 类肌钙蛋白（Calponin）亚型和生物学功能 |
| Calponin Isoforms and Biological Functions |
| Received:April 06, 2017 Revised:April 27, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.26.043 |
| 中文关键词: 类肌钙蛋白 亚型 蛋白质结构 细胞生物学功能 癌症 |
| 英文关键词: Calponin Isoform Protein structure Cell biological function Cancer |
| 基金项目: |
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| 中文摘要: |
| 摘要：Calponin（类肌钙蛋白）是一个肌动蛋白细肌丝相关的调节蛋白，表达在平滑肌细胞和许多类型的非肌细胞中。哺乳动物有Calponin 1、Calponin 2和Calponin 3三个亚型，分别由三个同源基因CNN1、CNN2和CNN3编码，表达于不同的细胞类型，并执行细胞类型特异性的生理功能。 除了调节平滑肌收缩功能，Calponin还调节非肌细胞肌动蛋白骨架的功能并参与多种细胞生命活动，如增殖、粘附、迁移、分化、吞噬和细胞融合等。本综述重点讨论Calponin亚型的基因进化、组织和细胞类型特异性表达、结构和功能的关系以及相关的调节机制。 |
| 英文摘要: |
| ABSTRACT: Calponin is an actin filament-associated regulatory protein expressed in smooth muscle and many types of nonmuscle cells. Three calponin isoforms 1, 2, and 3 are encoded by three homologous genes CNN1, CNN2 and CNN3 in vertebrate species with cell type-specific expression and functions. Besides modulating the activity of smooth muscle myofilaments and contractility, calponin also regulates the functions of actin cytoskeleton in non-muscle cells during cell proliferation, adhesion, migration, differentiation, phagocytosis and fusion. This review focuses on the evolution, tissue and cell type-specific expression, structure-function relationships, transcriptional regulation and relevant mechanisms. |
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