| 陆 叶,苗素琴,吕德珍,苏露露,高 红.氟比洛芬酯复合小剂量芬太尼对腹腔镜胆囊切除术患者镇痛效果及凝血功能的影响[J].现代生物医学进展英文版,2017,17(26):5181-5184. |
| 氟比洛芬酯复合小剂量芬太尼对腹腔镜胆囊切除术患者镇痛效果及凝血功能的影响 |
| Effect of Flurbiprofen Compound Small Dose Fentanyl on Intravenous Analgesia and Blood Coagulation Function of Patients with Laparoscopic Cholecystectomy |
| Received:March 01, 2017 Revised:March 29, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.26.042 |
| 中文关键词: 腹腔镜胆囊切除术 氟比洛芬酯 小剂量芬太尼 静脉自控镇痛 凝血功能 |
| 英文关键词: Laparoscopic cholecystectomy Flurbiprofen ester Small dose fentanyl Venous self-control analgesia Coagulation function |
| 基金项目:江苏省自然科学基金青年基金项目（BK20150555） |
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| 中文摘要: |
| 摘要 目的：探讨氟比洛芬酯复合小剂量芬太尼在腹腔镜胆囊切除术后静脉自控镇痛中的应用及对患者凝血功能的影响。方法：选择2015年11月~2016年11月于我院行腹腔镜胆囊切除术的患者102例，随机分为对照组和研究组，每组51例。对照组患者术后采用小剂量芬太尼静脉自控镇痛，研究组患者术后采用氟比洛芬酯复合小剂量芬太尼静脉自控镇痛。观察并比较两组患者手术前后血清纤维蛋白原（Fg），活化部分凝血酶原时间（APTT），凝血酶原时间（PT），血小板计数（PLT），P物质，5-烃色胺（5-HT），白细胞介素-6、8（IL-6、IL-8）水平以及术后并发症的发生情况。结果：术前，比较两组Fg、APTT、PT、PLT、P物质、5-HT、IL-6、IL-8无差异（P>0.05）；术后，两组Fg、APTT、PT、PLT、P物质、5-HT、IL-6、IL-8均较术前上升，研究组低于对照组，差异均有统计学意义（P<0.05）。研究组术后并发症率低于对照组（P<0.05）。结论：氟比洛芬酯复合小剂量芬太尼能够提高腹腔镜胆囊切除术患者静脉自控镇痛的效果，改善凝血功能，降低炎症因子水平。 |
| 英文摘要: |
| ABSTRACT Objective: To research the application of flurbiprofen compound small dose fentanyl with self-control vein analgesia after laparoscopic cholecystectomy and the influence on blood coagulation function. Methods: 102 cases with laparoscopic cholecystectomy who were treated in our hospital from November 2015 to November 2016 were selected and divided into the control group and the research group, with 51 cases in each group. The patients in the control group were treated with postoperative intravenous analgesia with low-dose fentanyl, while the patients in the research group were treated with postoperative intravenous analgesia with flurbiprofen ester compound low-dose fentanyl. Then the fibrinogen (Fg), activated partial prothrombin time (APTT), prothrombin time (PT), platelet count (PLT), substance P, 5-hydrocarbon serotonin (5-HT), interleukin 6, 8 (IL-6, IL-8) and complications between two groups were observed and compared. Results: Before treatment, there was no statistically significant difference about the Fg, APTT, PT, PLT, substance P, 5-HT, IL-6 and IL-8 between two groups (P>0.05); After treatment, the Fg, APTT, PT, PLT, substance P, 5-HT, IL-6 and IL-8 increased in the two groups, while the research group was lower than that of the control group, and the differences were statistically significant (P<0.05). The postoperative complication rate of research group was lower than that of the control group (P<0.05). Conclusion: Flurbiprofen ester compound small dose fentanyl with self-control vein analgesia can relieve coagulation function, and inhibit the levels of inflammatory factors. |
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