| 张英忠,王利娟,李少君,党赛利,赵 艳.经腹超声引导聚桂醇联合射频消融术治疗子宫肌瘤的临床疗效及对患者血清E2、LH、FSH水平的影响[J].现代生物医学进展英文版,2017,17(25):4936-4939. |
| 经腹超声引导聚桂醇联合射频消融术治疗子宫肌瘤的临床疗效及对患者血清E2、LH、FSH水平的影响 |
| Curative Efficacy of Transabdominal Ultrasound-guided Lauromacrogol Combined with Radiofrequency Ablation in Treatment of Fibroid and Its Effects on Serum E2 and LH FSH Levels |
| Received:March 06, 2017 Revised:March 25, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.25.033 |
| 中文关键词: 经腹超声 聚桂醇 射频消融术 子宫肌瘤 雌二醇(E2) 促卵泡生成素(FSH) 黄体生产素(LH) |
| 英文关键词: Transabdominal ultrasound Lauromacrogol Radiofrequency ablation Fibroid Estradiol Luteinizing hormone Follicle stimulating hormone |
| 基金项目:陕西省自然科学基金项目（2001B564） |
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| 中文摘要: |
| 摘要 目的：研究经腹超声引导聚桂醇联合射频消融术治疗子宫肌瘤的临床疗效及对患者血清雌二醇(E2)、黄体生产素(LH)、促卵泡生成素(FSH)水平的影响。方法：选取2014年6月至2015年6月我院接诊的90例子宫肌瘤患者作为本次研究对象，按照随机数表法将其分为观察组和对照组，每组45例。对照组采用经腹超声射频消融术治疗，观察组采用经腹超声引导聚桂醇联合射频消融术治疗。观察和比较两组患者治疗前后视觉模拟评分法(VAS)、月经量、肌瘤体积、子宫体积、血清E2、LH、FSH水平、肌瘤症状及生活质量评分的变化和治疗疗效。结果：治疗后，观察组总有效率显著高于对照组[95.55%(43/45)vs. 75.55%(34/45)] (P＜0.05)；VAS评分、月经量显著低于对照组[(1.05±0.23)分 vs. (3.62±0.50)分，(192.35±22.10)mL vs. (236.54±24.57)mL](P＜0.05)；肌瘤体积、子宫体积显著低于对照组[(32.13±13.20)cm3 vs. (40.81±14.11)cm3，(101.93±9.89)cm3 vs. (118.36±11.20)cm3](P＜0.05)；血清E2、LH、FSH水平显著低于治疗前，但两组比较差异无统计学意义(P＞0.05)；肌瘤症状评分显著低于对照组[(4.50±1.02)分vs(10.34±2.21)分] (P＜0.05)；生活质量评分显著高于对照组[(95.36±14.29)分vs(80.84±14.06)分](P＜0.05)。结论：经腹超声引导聚桂醇联合射频消融术治疗治疗子宫肌瘤可显著提高其临床疗效，可能与其显著降低血清E2、LH、FSH水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the curative efficacy of transabdominal ultrasound-guided Lauromacrogol combined with radiofrequency ablation in the treatment of fibroid and its effects on the serum estradiol(E2), luteinizing hormone (LH), follicle stimulating hormone (FSH) levels. Methods: 90 patients of fibroid who were treated from June 2014 to June 2015 in our hospital were selected as the research objects. According to random number table，those patients were divided into the observation group (n=45) and the control group (n=45). Both groups were routinely examined before operation, the control group was treated with transabdominal ultrasound radiofrequency ablation, while the observation group was treated with transabdominal ultrasound-guided percutaneous radiofrequency ablation combined with radiofrequency ablation, Then visual analogue scale (VAS), menstrual volume, uterine fibroid volume, uterine volume, E2, LH, FSH levels, myoma symptoms and quality of life score, curative effect were compared between two groups. Results: After treatment, the total effective rate of observation group was significantly higher than that of the control group[95.55%(43/45)vs75.55%(34/45)] (P＜0.05); the VAS score, menstrual volume were significantly lower than those of the control group[(1.05±0.23)score vs. (3.62±0.50)score, (192.35±22.10)mL l vs. (236.54±24.57)mL](P＜0.05); The myoma volume, uterine volume were significantly lower than those of the control group[(32.13±13.20)cm3 vs(40.81±14.11)cm3, (101.93±9.89)cm3 vs(118.36±11.20)cm3](P＜0.05); the serum E2, LH, FSH levels were significantly lower than those before treatment, but there was no difference between the two groups(P＞0.05); the fibroid symptoms score was significantly lower than that of the control group[(4.50±1.02)score vs. (10.34±2.21)score] (P＜0.05), the quality of life score was significantly higher than that of the control group[(95.36±14.29)score vs. (80.84±14.06)score](P＜0.05). Conclusion: Transabdominal ultrasound-guided lauromacrogol combined with radiofrequency ablation could enhance the efficacy of fibroid, which might be related to the decrease of serum levels of E2, LH, and FSH. |
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