| 邓跃林,于晓婷,李 凌,徐晓丽,孙 新,史红阳.肺炎支原体肺炎患儿外周血白介素的表达与肺功能变化的相关性[J].现代生物医学进展英文版,2017,17(25):4873-4875. |
| 肺炎支原体肺炎患儿外周血白介素的表达与肺功能变化的相关性 |
| Correlation between Lung Function and Peripheral Interleukin Expression of Mycoplasma Pneumonia Children |
| Received:November 26, 2016 Revised:December 20, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.25.017 |
| 中文关键词: 肺炎支原体肺炎 白介素IL-10 白介素IL-17 肺功能 |
| 英文关键词: Mycoplasma pneumoniae pneumonia IL-10 IL-17 Pulmonary Function |
| 基金项目:陕西省自然科学基础研究计划项目（2016JQ8054） |
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| 中文摘要: |
| 摘要 目的：探讨肺炎支原体（MPP）肺炎患儿外周血中IL-10、IL-17的表达水平与肺功能变化的相关性。方法：选取70例肺炎支原体肺炎患儿为研究对象，以是否有哮鸣音分为喘息组和非喘息组，以30例健康儿童为对照组，空腹采血5ml，分离血清，ELISA检测血清中IL-10、IL-17的表达水平，肺功能检测仪检测受检者的第一秒用力呼气容积（PEV1），最大呼气流量（PEF），用力肺活量（FEV1/FVC）。结果：喘息组中IL-10的表达水平与对照组相比差异显著（P<0.05），喘息组中IL-10的表达水平与非喘息组相比差异显著（P<0.05），喘息组中IL-17的表达水平与对照组相比差异显著（P<0.05），喘息组中IL-17的表达水平与非喘息组相比差异显著（P<0.05）。喘息组和非喘息组中IL-10水平均低于对照组，喘息组和非喘息组中IL-17水平均高于于对照组。非喘息组较喘息组PEV1、PEF、PVE1/FVC值高，差异显著（P<0.05）。肺炎支原体肺炎患儿血清中的IL-10的水平与PEV1、PEF、PVE1/FVC呈正相关，肺炎支原体肺炎患儿血清中的IL-17的水平与PEV1、PEF、PVE1/FVC呈负相关。结论：肺炎支原体肺炎患儿血清中IL-10、IL-17的表达水平与肺功能密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between IL-10 and Il-17 expression levels in Mycoplasma pneumoniae pneu- monia (MPP) and lung function. Methods: 70 patients were included in this study. According to wheezing or not, they were divided into wheezing group and non-wheezing group. Another 30 healthy children were taken as a control group. After taking fasting blood 5ml, the serum IL-10 and IL-17 expression levels were detected by ELISA. The forced expiratory volume in one second (PEV1), peak expiratory flow (PEF) and forced vital capacity (FEV1 / FVC) of all subjects were detected. Results: The IL-10 expression level of the wheezing group were significantly different with that of the control group (P<0.05) and that of the non-wheezing group (P<0.05). The IL-17 expres- sion level of the wheezing group also had significant difference (P<0.05) with that of the control group and non-wheezing group (P<0.05). The IL-10 expression levels of wheezing and non-wheezing group all were lower than that of the control group. Whereas the IL-17 expression levels of wheezing and non-wheezing group all were higher than that in the control group. In addition, patients in wheezing group had higher PEV1, PEF, PVE1/FVC values than those in non-wheezing group, with significant difference (P<0.05). The serum level of IL-10 expression of Mycoplasma pneumonia patients was positively correlated with PEV1, PEF and PVE1/FVC, while the serum level of IL-17 expression of Mycoplasma pneumonia patients was negatively correlated with PEV1, PEF and PVE1/FVC. Conclusion: The serum levels of IL-17 and IL-10 expression of Mycoplasma pneumonia children had close correlation with their pulmonary function. |
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